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실시간 박테리아 감지를 위한 정전용량방식의 MEMS 바이오센서

Other Titles
 MEMS based capacitive biosensor for real time detection of bacterial growth 
 서혜경  ;  임대호  ;  임미화  ;  김종백  ;  신전수  ;  김용준 
 Journal of Sensor Science and Technology (센서학회지), Vol.17(3) : 195-202, 2008 
Journal Title
 Journal of Sensor Science and Technology (센서학회지) 
Issue Date
Impedance microbiology ; real time detection of bacteria ; capacitance ; interdigitated microelectrode (IME)
A biosensor based on the measurement of capacitance changes has been designed and fabricated for simple and realtime detection of bacteria. Compared to an impedance measurement technique, the capacitance measurement can make additional measurement circuits simpler, which improves a compatability for integration between the sensor and circuit. The fabricated sensor was characterized by detecting Escherichia coli(E. coli). The capacitance changes measured by the sensor were proportional to E. coli cell density, and the proposed sensor could detect 1X106 cfu/ml E. coli at least. The real-time detection was verified by measuring the capacitance every 20 minutes. After 7 hours of E. coli growth experiment, the capacitance of the sensor in the micro volume well with $4.5{\times}10^5$ cfu/ml of initial E. coli density increased by 20 pF, and that in another wells with $1.5{\times}10^6$ cfu/ml and $8.5{\times}10^7$ cfu/ml initial E. coli density increased by 56 pF and 71 pF, respectively. The proposed sensor has a possibility of the real-time detection for bacterial growth, and can detect E. coli cells with $1.8{\times}10^5$ cfu in nutrient broth in 5 hours
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Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Microbiology (미생물학교실) > 1. Journal Papers
Yonsei Authors
Shin, Jeon Soo(신전수) ORCID logo https://orcid.org/0000-0002-8294-3234
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