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MLL rearrangement with t(6;11)(q15;q23) as a sole abnormality in a patient with de novo acute myeloid leukemia: conventional cytogenetics, FISH, and multicolor FISH analyses for detection of rare MLL-related chromosome abnormalities.

Authors
 Tae Sung Park  ;  Seung Tae Lee  ;  Jaewoo Song  ;  Kyung-A Lee  ;  Sang-Guk Lee  ;  Juwon Kim  ;  Borum Suh  ;  Sue Jung Kim  ;  Jong-Han Lee  ;  Rojin Park  ;  Jong Rak Choi 
Citation
 CANCER GENETICS AND CYTOGENETICS , Vol.187(1) : 50-53, 2008 
Journal Title
 CANCER GENETICS AND CYTOGENETICS 
ISSN
 0165-4608 
Issue Date
2008
MeSH
Bone Marrow/pathology ; Chromosome Aberrations/classification* ; Chromosome Mapping ; Chromosomes, Human, Pair 11* ; Chromosomes, Human, Pair 6* ; Female ; Flow Cytometry ; Gene Rearrangement* ; Histone-Lysine N-Methyltransferase ; Humans ; In Situ Hybridization, Fluorescence ; Karyotyping ; Leukemia, Myeloid, Acute/genetics* ; Leukemia, Myeloid, Acute/pathology ; Middle Aged ; Myeloid-Lymphoid Leukemia Protein/genetics* ; Translocation, Genetic*
Keywords
Bone Marrow/pathology ; Chromosome Aberrations/classification* ; Chromosome Mapping ; Chromosomes, Human, Pair 11* ; Chromosomes, Human, Pair 6* ; Female ; Flow Cytometry ; Gene Rearrangement* ; Histone-Lysine N-Methyltransferase ; Humans ; In Situ Hybridization, Fluorescence ; Karyotyping ; Leukemia, Myeloid, Acute/genetics* ; Leukemia, Myeloid, Acute/pathology ; Middle Aged ; Myeloid-Lymphoid Leukemia Protein/genetics* ; Translocation, Genetic*
Abstract
We report a rare case of acute myeloid leukemia (AML) with t(6;11)(q15;q23) in a 50-year-old female showing a poor prognosis. Bone marrow biopsy revealed markedly hypercellular marrow with infiltrates of myeloblasts, consistent with AML-M2 morphology. The karyotype of this patient was 46,XX,t(6;11)(q15;q23) in all analyzed cells, and the results of fluorescence in situ hybridization (FISH) and multi-color FISH analysis confirmed this unique MLL rearrangement as a sole abnormality. To our knowledge, t(6;11)(q13 approximately q15;q23) is the most rare type of MLL rearrangement involving the long arm of chromosome 6. Only two cases with t(6;11)(q13;q23) and three cases with t(6;11)(q15;q23) have been reported, but detailed clinical or laboratory data were not available. From this report, it is apparent that in a cytogenetic laboratory, the accurate detection of a rare type of MLL rearrangement is very important in the differential diagnosis, prompt treatment, and prediction of prognosis of leukemias
Full Text
http://www.sciencedirect.com/science/article/pii/S0165460808004688
DOI
10.1016/j.cancergencyto.2008.07.012
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers
Yonsei Authors
Park, Tae Sung(박태성)
Song, Jae Woo(송재우) ORCID logo https://orcid.org/0000-0002-1877-5731
Lee, Kyung A(이경아) ORCID logo https://orcid.org/0000-0001-5320-6705
Lee, Sang-Guk(이상국) ORCID logo https://orcid.org/0000-0003-3862-3660
Lee, Seung Tae(이승태)
Lee, Jong Han(이종한)
Choi, Jong Rak(최종락) ORCID logo https://orcid.org/0000-0002-0608-2989
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/108196
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