Cited 5 times in
MLL rearrangement with t(6;11)(q15;q23) as a sole abnormality in a patient with de novo acute myeloid leukemia: conventional cytogenetics, FISH, and multicolor FISH analyses for detection of rare MLL-related chromosome abnormalities.
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 박태성 | - |
dc.contributor.author | 송재우 | - |
dc.contributor.author | 이경아 | - |
dc.contributor.author | 이승태 | - |
dc.contributor.author | 이종한 | - |
dc.contributor.author | 최종락 | - |
dc.contributor.author | 이상국 | - |
dc.date.accessioned | 2015-05-19T17:27:51Z | - |
dc.date.available | 2015-05-19T17:27:51Z | - |
dc.date.issued | 2008 | - |
dc.identifier.issn | 0165-4608 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/108196 | - |
dc.description.abstract | We report a rare case of acute myeloid leukemia (AML) with t(6;11)(q15;q23) in a 50-year-old female showing a poor prognosis. Bone marrow biopsy revealed markedly hypercellular marrow with infiltrates of myeloblasts, consistent with AML-M2 morphology. The karyotype of this patient was 46,XX,t(6;11)(q15;q23) in all analyzed cells, and the results of fluorescence in situ hybridization (FISH) and multi-color FISH analysis confirmed this unique MLL rearrangement as a sole abnormality. To our knowledge, t(6;11)(q13 approximately q15;q23) is the most rare type of MLL rearrangement involving the long arm of chromosome 6. Only two cases with t(6;11)(q13;q23) and three cases with t(6;11)(q15;q23) have been reported, but detailed clinical or laboratory data were not available. From this report, it is apparent that in a cytogenetic laboratory, the accurate detection of a rare type of MLL rearrangement is very important in the differential diagnosis, prompt treatment, and prediction of prognosis of leukemias | - |
dc.description.statementOfResponsibility | open | - |
dc.relation.isPartOf | CANCER GENETICS AND CYTOGENETICS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Bone Marrow/pathology | - |
dc.subject.MESH | Chromosome Aberrations/classification* | - |
dc.subject.MESH | Chromosome Mapping | - |
dc.subject.MESH | Chromosomes, Human, Pair 11* | - |
dc.subject.MESH | Chromosomes, Human, Pair 6* | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Flow Cytometry | - |
dc.subject.MESH | Gene Rearrangement* | - |
dc.subject.MESH | Histone-Lysine N-Methyltransferase | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | In Situ Hybridization, Fluorescence | - |
dc.subject.MESH | Karyotyping | - |
dc.subject.MESH | Leukemia, Myeloid, Acute/genetics* | - |
dc.subject.MESH | Leukemia, Myeloid, Acute/pathology | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Myeloid-Lymphoid Leukemia Protein/genetics* | - |
dc.subject.MESH | Translocation, Genetic* | - |
dc.title | MLL rearrangement with t(6;11)(q15;q23) as a sole abnormality in a patient with de novo acute myeloid leukemia: conventional cytogenetics, FISH, and multicolor FISH analyses for detection of rare MLL-related chromosome abnormalities. | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학) | - |
dc.contributor.googleauthor | Tae Sung Park | - |
dc.contributor.googleauthor | Seung Tae Lee | - |
dc.contributor.googleauthor | Jaewoo Song | - |
dc.contributor.googleauthor | Kyung-A Lee | - |
dc.contributor.googleauthor | Sang-Guk Lee | - |
dc.contributor.googleauthor | Juwon Kim | - |
dc.contributor.googleauthor | Borum Suh | - |
dc.contributor.googleauthor | Sue Jung Kim | - |
dc.contributor.googleauthor | Jong-Han Lee | - |
dc.contributor.googleauthor | Rojin Park | - |
dc.contributor.googleauthor | Jong Rak Choi | - |
dc.identifier.doi | 10.1016/j.cancergencyto.2008.07.012 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A01725 | - |
dc.contributor.localId | A02054 | - |
dc.contributor.localId | A02647 | - |
dc.contributor.localId | A02930 | - |
dc.contributor.localId | A03151 | - |
dc.contributor.localId | A04182 | - |
dc.relation.journalcode | J00443 | - |
dc.identifier.eissn | 1873-4456 | - |
dc.identifier.pmid | 18992643 | - |
dc.identifier.url | http://www.sciencedirect.com/science/article/pii/S0165460808004688 | - |
dc.subject.keyword | Bone Marrow/pathology | - |
dc.subject.keyword | Chromosome Aberrations/classification* | - |
dc.subject.keyword | Chromosome Mapping | - |
dc.subject.keyword | Chromosomes, Human, Pair 11* | - |
dc.subject.keyword | Chromosomes, Human, Pair 6* | - |
dc.subject.keyword | Female | - |
dc.subject.keyword | Flow Cytometry | - |
dc.subject.keyword | Gene Rearrangement* | - |
dc.subject.keyword | Histone-Lysine N-Methyltransferase | - |
dc.subject.keyword | Humans | - |
dc.subject.keyword | In Situ Hybridization, Fluorescence | - |
dc.subject.keyword | Karyotyping | - |
dc.subject.keyword | Leukemia, Myeloid, Acute/genetics* | - |
dc.subject.keyword | Leukemia, Myeloid, Acute/pathology | - |
dc.subject.keyword | Middle Aged | - |
dc.subject.keyword | Myeloid-Lymphoid Leukemia Protein/genetics* | - |
dc.subject.keyword | Translocation, Genetic* | - |
dc.contributor.alternativeName | Park, Tae Sung | - |
dc.contributor.alternativeName | Song, Jae Woo | - |
dc.contributor.alternativeName | Lee, Kyung A | - |
dc.contributor.alternativeName | Lee, Seung Tae | - |
dc.contributor.alternativeName | Lee, Jong Han | - |
dc.contributor.alternativeName | Choi, Jong Rak | - |
dc.contributor.affiliatedAuthor | Park, Tae Sung | - |
dc.contributor.affiliatedAuthor | Song, Jae Woo | - |
dc.contributor.affiliatedAuthor | Lee, Kyung A | - |
dc.contributor.affiliatedAuthor | Lee, Seung Tae | - |
dc.contributor.affiliatedAuthor | Lee, Jong Han | - |
dc.contributor.affiliatedAuthor | Choi, Jong Rak | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 187 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 50 | - |
dc.citation.endPage | 53 | - |
dc.identifier.bibliographicCitation | CANCER GENETICS AND CYTOGENETICS , Vol.187(1) : 50-53, 2008 | - |
dc.identifier.rimsid | 35244 | - |
dc.type.rims | ART | - |
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