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Utility of QuantiFERON-TB In-Tube Test for Differentiating Active Tuberculosis from Latent Tuberculosis Infection in an Intermediate Burden Country

 Suk Hoon Choi  ;  Bum Sik Chin  ;  Sang Hoon Han  ;  Han Sung Lee  ;  Chang Oh Kim  ;  Su Jin Jeong  ;  Hee Kyung Choi  ;  Myung Soo Kim  ;  Jun Yong Choi  ;  Young Goo Song  ;  June Myung Kim 
 Infection and Chemotherapy (감염과 화학요법), Vol.40(6) : 305-310, 2008 
Journal Title
 Infection and Chemotherapy  (감염과 화학요법) 
Issue Date
BACKGROUND: The aim of the present study was to assess the contribution of a QuantiFERON-TB Gold In-Tube test (QFT-IT) in differentiating active tuberculosis (TB) from latent tuberculosis infection (LTBI) by quantifying interferon-gamma levels. MATERIALS AND METHODS: We retrospectively reviewed clinical records of 314 patients older than 15 years who had performed QFT-IT between July 2006 and August 2007 at a tertiary care teaching hospital. RESULTS: Subjects with active TB (n=81, culture confirmed active TB in 40 subjects) and LTBI (n=76) were included. Mean+/-SD IFN-gamma levels were 4.96+/-3.98 IU/mL (range -0.08-10) for all subjects with active TB, 4.54+/-4.05 IU/mL (range -0.08-10) for culture confirmed active TB, and 4.11+/-3.57 IU/mL (range 0.35-10) for subjects with LTBI. The quantitative results of QFT-IT on IFN-gamma levels between all the subjects with active TB and those with LTBI were not statistically significant (P=0.16). The result was similar when compared between those with culture confirmed active TB and those with LTBI, showing little statistical significance (P=0.554). CONCLUSION: The production of IFN-gamma measured by QFT-IT showed no correlation between its level and the activity of Mycobacterium tuberculosis infection. These results suggest that measuring IFN-gamma using QFT-IT might not be useful for distinguishing active TB from LTBI
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1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
김명수(Kim, Myoung Soo)
김준명(Kim, June Myung)
김창오(Kim, Chang Oh) ORCID logo https://orcid.org/0000-0002-0773-5443
송영구(Song, Young Goo) ORCID logo https://orcid.org/0000-0002-0733-4156
이한성(Lee, Han Sung)
정수진(Jeong, Su Jin) ORCID logo https://orcid.org/0000-0003-4025-4542
진범식(Chin, Bum Sik)
최석훈(Choi, Suk Hoon)
최준용(Choi, Jun Yong) ORCID logo https://orcid.org/0000-0002-2775-3315
최희경(Choi, Hee Kyoung)
한상훈(Han, Sang Hoon) ORCID logo https://orcid.org/0000-0002-4278-5198
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