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Utility of QuantiFERON-TB In-Tube Test for Differentiating Active Tuberculosis from Latent Tuberculosis Infection in an Intermediate Burden Country
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김명수 | - |
dc.contributor.author | 김준명 | - |
dc.contributor.author | 김창오 | - |
dc.contributor.author | 송영구 | - |
dc.contributor.author | 이한성 | - |
dc.contributor.author | 정수진 | - |
dc.contributor.author | 진범식 | - |
dc.contributor.author | 최석훈 | - |
dc.contributor.author | 최준용 | - |
dc.contributor.author | 최희경 | - |
dc.contributor.author | 한상훈 | - |
dc.date.accessioned | 2015-05-19T17:21:32Z | - |
dc.date.available | 2015-05-19T17:21:32Z | - |
dc.date.issued | 2008 | - |
dc.identifier.issn | 1598-8112 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/107996 | - |
dc.description.abstract | BACKGROUND: The aim of the present study was to assess the contribution of a QuantiFERON-TB Gold In-Tube test (QFT-IT) in differentiating active tuberculosis (TB) from latent tuberculosis infection (LTBI) by quantifying interferon-gamma levels. MATERIALS AND METHODS: We retrospectively reviewed clinical records of 314 patients older than 15 years who had performed QFT-IT between July 2006 and August 2007 at a tertiary care teaching hospital. RESULTS: Subjects with active TB (n=81, culture confirmed active TB in 40 subjects) and LTBI (n=76) were included. Mean+/-SD IFN-gamma levels were 4.96+/-3.98 IU/mL (range -0.08-10) for all subjects with active TB, 4.54+/-4.05 IU/mL (range -0.08-10) for culture confirmed active TB, and 4.11+/-3.57 IU/mL (range 0.35-10) for subjects with LTBI. The quantitative results of QFT-IT on IFN-gamma levels between all the subjects with active TB and those with LTBI were not statistically significant (P=0.16). The result was similar when compared between those with culture confirmed active TB and those with LTBI, showing little statistical significance (P=0.554). CONCLUSION: The production of IFN-gamma measured by QFT-IT showed no correlation between its level and the activity of Mycobacterium tuberculosis infection. These results suggest that measuring IFN-gamma using QFT-IT might not be useful for distinguishing active TB from LTBI | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 305~310 | - |
dc.relation.isPartOf | INFECTION AND CHEMOTHERAPY (감염과 화학요법) | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Utility of QuantiFERON-TB In-Tube Test for Differentiating Active Tuberculosis from Latent Tuberculosis Infection in an Intermediate Burden Country | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학) | - |
dc.contributor.googleauthor | Suk Hoon Choi | - |
dc.contributor.googleauthor | Bum Sik Chin | - |
dc.contributor.googleauthor | Sang Hoon Han | - |
dc.contributor.googleauthor | Han Sung Lee | - |
dc.contributor.googleauthor | Chang Oh Kim | - |
dc.contributor.googleauthor | Su Jin Jeong | - |
dc.contributor.googleauthor | Hee Kyung Choi | - |
dc.contributor.googleauthor | Myung Soo Kim | - |
dc.contributor.googleauthor | Jun Yong Choi | - |
dc.contributor.googleauthor | Young Goo Song | - |
dc.contributor.googleauthor | June Myung Kim | - |
dc.identifier.doi | 10.3947/ic.2008.40.6.305 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00953 | - |
dc.contributor.localId | A01044 | - |
dc.contributor.localId | A02037 | - |
dc.contributor.localId | A03277 | - |
dc.contributor.localId | A03638 | - |
dc.contributor.localId | A03981 | - |
dc.contributor.localId | A04071 | - |
dc.contributor.localId | A04191 | - |
dc.contributor.localId | A04228 | - |
dc.contributor.localId | A04286 | - |
dc.contributor.localId | A00423 | - |
dc.relation.journalcode | J01054 | - |
dc.identifier.pmid | Tuberculosis ; Latent tuberculosis ; Interferon-γ | - |
dc.subject.keyword | Tuberculosis | - |
dc.subject.keyword | Latent tuberculosis | - |
dc.subject.keyword | Interferon-γ | - |
dc.contributor.alternativeName | Kim, Myoung Soo | - |
dc.contributor.alternativeName | Kim, June Myung | - |
dc.contributor.alternativeName | Kim, Chang Oh | - |
dc.contributor.alternativeName | Song, Young Goo | - |
dc.contributor.alternativeName | Lee, Han Sung | - |
dc.contributor.alternativeName | Jeong, Su Jin | - |
dc.contributor.alternativeName | Chin, Bum Sik | - |
dc.contributor.alternativeName | Choi, Suk Hoon | - |
dc.contributor.alternativeName | Choi, Jun Yong | - |
dc.contributor.alternativeName | Choi, Hee Kyoung | - |
dc.contributor.alternativeName | Han, Sang Hoon | - |
dc.contributor.affiliatedAuthor | Kim, June Myung | - |
dc.contributor.affiliatedAuthor | Kim, Chang Oh | - |
dc.contributor.affiliatedAuthor | Song, Young Goo | - |
dc.contributor.affiliatedAuthor | Lee, Han Sung | - |
dc.contributor.affiliatedAuthor | Jeong, Su Jin | - |
dc.contributor.affiliatedAuthor | Chin, Bum Sik | - |
dc.contributor.affiliatedAuthor | Choi, Suk Hoon | - |
dc.contributor.affiliatedAuthor | Choi, Jun Yong | - |
dc.contributor.affiliatedAuthor | Choi, Hee Kyoung | - |
dc.contributor.affiliatedAuthor | Han, Sang Hoon | - |
dc.contributor.affiliatedAuthor | Kim, Myoung Soo | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 40 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 305 | - |
dc.citation.endPage | 310 | - |
dc.identifier.bibliographicCitation | INFECTION AND CHEMOTHERAPY (감염과 화학요법), Vol.40(6) : 305-310, 2008 | - |
dc.identifier.rimsid | 50050 | - |
dc.type.rims | ART | - |
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