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The role of a whole blood interferon-gamma assay for the detection of latent tuberculosis infection in Bacille Calmette-Guérin vaccinated children

Authors
 Jin-Kyong Chun  ;  Chang Ki Kim  ;  Hyon-Suk Kim  ;  Ghee Young Jung  ;  Taek Jin Lee  ;  Ki Hwan Kim  ;  Dong Soo Kim 
Citation
 DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE, Vol.62(4) : 389-394, 2008 
Journal Title
 DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE 
ISSN
 0732-8893 
Issue Date
2008
MeSH
BCG Vaccine/immunology* ; Child, Preschool ; Contact Tracing ; Female ; Humans ; Infant ; Infant, Newborn ; Interferon-gamma/blood* ; Male ; Tuberculosis/blood ; Tuberculosis/diagnosis* ; Tuberculosis/epidemiology
Keywords
Interferon-γ release test ; Tuberculosis ; Children
Abstract
The tuberculin skin test (TST) has limitations in children who are under the Bacille Calmette-Guérin (BCG) effect. Our aim was to evaluate the QuantiFERON-TB Gold In-Tube (QFT-G IT) blood test for Mycobacterium tuberculosis infection in children and to compare results with those of the TST. QFT-G IT and TST data were collected from 227 children between 0 and 15 years of age, split into 4 risk groups. Forty-two children were close contacts, 29 were casual contacts, and 65 were controls. The QFT-G IT positivity rates were 19% (8/42), 6.9% (2/29), and 1.5% (1/65), with a significantly higher rate for the close contacts over the controls (P < 0.05). The high specificity of the QFT-G IT assay and the association of positive results with increasing risk of infection in our study suggest it has major benefits over the TST as a screening test for latent infection with M. tuberculosis in BCG-vaccinated children.
Full Text
http://www.sciencedirect.com/science/article/pii/S0732889308003982
DOI
10.1016/j.diagmicrobio.2008.08.022
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pediatrics (소아청소년과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers
Yonsei Authors
Kim, Ki Hwan(김기환)
Kim, Dong Soo(김동수)
Kim, Hyon Suk(김현숙) ORCID logo https://orcid.org/0000-0001-5662-7740
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/107898
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