Cited 48 times in
The role of a whole blood interferon-gamma assay for the detection of latent tuberculosis infection in Bacille Calmette-Guérin vaccinated children
DC Field | Value | Language |
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dc.contributor.author | 김기환 | - |
dc.contributor.author | 김동수 | - |
dc.contributor.author | 김현숙 | - |
dc.date.accessioned | 2015-05-19T17:18:28Z | - |
dc.date.available | 2015-05-19T17:18:28Z | - |
dc.date.issued | 2008 | - |
dc.identifier.issn | 0732-8893 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/107898 | - |
dc.description.abstract | The tuberculin skin test (TST) has limitations in children who are under the Bacille Calmette-Guérin (BCG) effect. Our aim was to evaluate the QuantiFERON-TB Gold In-Tube (QFT-G IT) blood test for Mycobacterium tuberculosis infection in children and to compare results with those of the TST. QFT-G IT and TST data were collected from 227 children between 0 and 15 years of age, split into 4 risk groups. Forty-two children were close contacts, 29 were casual contacts, and 65 were controls. The QFT-G IT positivity rates were 19% (8/42), 6.9% (2/29), and 1.5% (1/65), with a significantly higher rate for the close contacts over the controls (P < 0.05). The high specificity of the QFT-G IT assay and the association of positive results with increasing risk of infection in our study suggest it has major benefits over the TST as a screening test for latent infection with M. tuberculosis in BCG-vaccinated children. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 389~394 | - |
dc.relation.isPartOf | DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | BCG Vaccine/immunology* | - |
dc.subject.MESH | Child, Preschool | - |
dc.subject.MESH | Contact Tracing | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Infant | - |
dc.subject.MESH | Infant, Newborn | - |
dc.subject.MESH | Interferon-gamma/blood* | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Tuberculosis/blood | - |
dc.subject.MESH | Tuberculosis/diagnosis* | - |
dc.subject.MESH | Tuberculosis/epidemiology | - |
dc.title | The role of a whole blood interferon-gamma assay for the detection of latent tuberculosis infection in Bacille Calmette-Guérin vaccinated children | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Pediatrics (소아과학) | - |
dc.contributor.googleauthor | Jin-Kyong Chun | - |
dc.contributor.googleauthor | Chang Ki Kim | - |
dc.contributor.googleauthor | Hyon-Suk Kim | - |
dc.contributor.googleauthor | Ghee Young Jung | - |
dc.contributor.googleauthor | Taek Jin Lee | - |
dc.contributor.googleauthor | Ki Hwan Kim | - |
dc.contributor.googleauthor | Dong Soo Kim | - |
dc.identifier.doi | 10.1016/j.diagmicrobio.2008.08.022 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00344 | - |
dc.contributor.localId | A01117 | - |
dc.contributor.localId | A00405 | - |
dc.relation.journalcode | J00731 | - |
dc.identifier.eissn | 1879-0070 | - |
dc.identifier.pmid | 18990532 | - |
dc.identifier.url | http://www.sciencedirect.com/science/article/pii/S0732889308003982 | - |
dc.subject.keyword | Interferon-γ release test | - |
dc.subject.keyword | Tuberculosis | - |
dc.subject.keyword | Children | - |
dc.contributor.alternativeName | Kim, Ki Hwan | - |
dc.contributor.alternativeName | Kim, Dong Soo | - |
dc.contributor.alternativeName | Kim, Hyon Suk | - |
dc.contributor.affiliatedAuthor | Kim, Ki Hwan | - |
dc.contributor.affiliatedAuthor | Kim, Hyon Suk | - |
dc.contributor.affiliatedAuthor | Kim, Dong Soo | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 62 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 389 | - |
dc.citation.endPage | 394 | - |
dc.identifier.bibliographicCitation | DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE, Vol.62(4) : 389-394, 2008 | - |
dc.identifier.rimsid | 34762 | - |
dc.type.rims | ART | - |
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