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Clinical characteristics and prognosis of orbital invasive aspergillosis

Authors
 Hye Sun Choi  ;  Jun Yong Choi  ;  Jin Sook Yoon  ;  Sung Joo Kim  ;  Sang Yeul Lee 
Citation
 Ophthalmic Plastic and Reconstructive Surgery, Vol.24(6) : 454-459, 2008 
Journal Title
 Ophthalmic Plastic and Reconstructive Surgery 
ISSN
 0740-9303 
Issue Date
2008
MeSH
Aged ; Aged, 80 and over ; Antifungal Agents/therapeutic use ; Aspergillosis/diagnosis* ; Aspergillosis/epidemiology ; Aspergillosis/therapy ; Debridement/methods ; Diagnosis, Differential ; Diagnostic Errors ; Eye Infections, Fungal/diagnosis* ; Eye Infections, Fungal/epidemiology ; Eye Infections, Fungal/therapy ; Female ; Follow-Up Studies ; Hospital Mortality/trends ; Humans ; Incidence ; Korea/epidemiology ; Male ; Middle Aged ; Ophthalmologic Surgical Procedures/methods ; Orbit ; Prognosis ; Retrospective Studies ; Risk Factors ; Survival Rate/trends ; Tomography, X-Ray Computed
Keywords
Aged ; Aged, 80 and over ; Antifungal Agents/therapeutic use ; Aspergillosis/diagnosis* ; Aspergillosis/epidemiology ; Aspergillosis/therapy ; Debridement/methods ; Diagnosis, Differential ; Diagnostic Errors ; Eye Infections, Fungal/diagnosis* ; Eye Infections, Fungal/epidemiology ; Eye Infections, Fungal/therapy ; Female ; Follow-Up Studies ; Hospital Mortality/trends ; Humans ; Incidence ; Korea/epidemiology ; Male ; Middle Aged ; Ophthalmologic Surgical Procedures/methods ; Orbit ; Prognosis ; Retrospective Studies ; Risk Factors ; Survival Rate/trends ; Tomography, X-Ray Computed
Abstract
PURPOSE: To evaluate the clinical characteristics and prognosis of orbital invasive aspergillosis, a major cause of morbidity and mortality in immunocompromised patients. METHODS: Review of the medical records of Severance Hospital, Yonsei University College of Medicine, from 1995 to 2007 revealed 15 patients with orbital invasive aspergillosis. A retrospective cohort study was conducted to evaluate the clinical characteristics, radiologic findings, associated underlying diseases, and prognosis. Risk factors for mortality were analyzed. RESULTS: A total of 15 cases of orbital invasive aspergillosis were included in this study. The mean age for all patients was 61.9 years. The most common underlying disease was diabetes mellitus and all patients had paranasal sinus infections. The most common ocular symptoms were visual disturbance, periorbital swelling, and periorbital pain. The mortality rate associated with invasive aspergillosis was 40%. According to univariate analysis, variables significantly associated with invasive aspergillosis-related mortality included fever and incorrect initial diagnosis. CONCLUSIONS: Fever and incorrect initial diagnosis were found to be associated with high mortality rates in patients with orbital invasive aspergillosis. Further study is necessary to determine optimal strategies for early diagnosis and appropriate treatment
Full Text
http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&AN=00002341-200811000-00006&LSLINK=80&D=ovft
DOI
10.1097/IOP.0b013e31818c99ff
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Ophthalmology (안과학교실) > 1. Journal Papers
Yonsei Authors
Yoon, Jin Sook(윤진숙) ORCID logo https://orcid.org/0000-0002-8751-9467
Lee, Sang Yeul(이상열)
Choi, Jun Yong(최준용) ORCID logo https://orcid.org/0000-0002-2775-3315
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/107811
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