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Autocrine function of erythropoietin in IGF-1-induced erythropoietin biosynthesis

Authors
 Insook Kim  ;  Chul Hoon Kim  ;  Yeong Shin Yim  ;  Young Soo Ahn 
Citation
 NEUROREPORT, Vol.19(17) : 1699-1703, 2008 
Journal Title
 NEUROREPORT 
ISSN
 0959-4965 
Issue Date
2008
MeSH
Antibodies/immunology ; Antibodies/pharmacology ; Astrocytoma/genetics ; Astrocytoma/metabolism ; Astrocytoma/pathology ; Autocrine Communication/drug effects ; Autocrine Communication/physiology ; Blotting, Western ; Cell Line, Tumor ; Enzyme-Linked Immunosorbent Assay ; Erythropoietin/genetics ; Erythropoietin/metabolism ; Erythropoietin/physiology* ; Gene Expression Regulation ; Humans ; Hypoxia-Inducible Factor 1/genetics ; Hypoxia-Inducible Factor 1/metabolism ; Hypoxia-Inducible Factor 1/physiology* ; Insulin-Like Growth Factor I/pharmacology* ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; Receptors, Erythropoietin/genetics ; Receptors, Erythropoietin/immunology ; Receptors, Erythropoietin/metabolism ; Reverse Transcriptase Polymerase Chain Reaction ; Transcriptional Activation
Keywords
astrocytes ; erythropoietin ; hypoxia-inducible factor-1 ; insulin-like growth factor-1
Abstract
Insulin-like growth factor-1 (IGF-1) and erythropoietin (EPO) are induced in brain cells after brain ischemia and show synergistic neuroprotective effects. In LN215 astrocytoma cells, IGF-1 induced the activation of hypoxia-inducible factor-1, leading to increases in EPO mRNA levels and the secretion of EPO. Interestingly, blocking the potential action of secreted EPO on LN215 cells with EPO antibody, EPO receptor antibody, and soluble EPO receptor significantly suppressed the effect of IGF-1 on the biosynthesis of EPO. Synergistic action between IGF-1 and recombinant human EPO in the astrocytic production of EPO was observed. These data suggest that the IGF-1-EPO production/secretion process initiates a positive feedback loop of EPO biosynthesis in astrocytes, providing a molecular link between the two neuroprotective cytokines
Full Text
http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&AN=00001756-200811190-00010&LSLINK=80&D=ovft
DOI
10.1097/WNR.0b013e32831743fb
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pharmacology (약리학교실) > 1. Journal Papers
Yonsei Authors
Kim, Chul Hoon(김철훈) ORCID logo https://orcid.org/0000-0002-7360-429X
Ahn, Young Soo(안영수)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/107781
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