Cited 10 times in
Autocrine function of erythropoietin in IGF-1-induced erythropoietin biosynthesis
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김철훈 | - |
dc.contributor.author | 안영수 | - |
dc.date.accessioned | 2015-05-19T17:14:47Z | - |
dc.date.available | 2015-05-19T17:14:47Z | - |
dc.date.issued | 2008 | - |
dc.identifier.issn | 0959-4965 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/107781 | - |
dc.description.abstract | Insulin-like growth factor-1 (IGF-1) and erythropoietin (EPO) are induced in brain cells after brain ischemia and show synergistic neuroprotective effects. In LN215 astrocytoma cells, IGF-1 induced the activation of hypoxia-inducible factor-1, leading to increases in EPO mRNA levels and the secretion of EPO. Interestingly, blocking the potential action of secreted EPO on LN215 cells with EPO antibody, EPO receptor antibody, and soluble EPO receptor significantly suppressed the effect of IGF-1 on the biosynthesis of EPO. Synergistic action between IGF-1 and recombinant human EPO in the astrocytic production of EPO was observed. These data suggest that the IGF-1-EPO production/secretion process initiates a positive feedback loop of EPO biosynthesis in astrocytes, providing a molecular link between the two neuroprotective cytokines | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 1699~1703 | - |
dc.relation.isPartOf | NEUROREPORT | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Antibodies/immunology | - |
dc.subject.MESH | Antibodies/pharmacology | - |
dc.subject.MESH | Astrocytoma/genetics | - |
dc.subject.MESH | Astrocytoma/metabolism | - |
dc.subject.MESH | Astrocytoma/pathology | - |
dc.subject.MESH | Autocrine Communication/drug effects | - |
dc.subject.MESH | Autocrine Communication/physiology | - |
dc.subject.MESH | Blotting, Western | - |
dc.subject.MESH | Cell Line, Tumor | - |
dc.subject.MESH | Enzyme-Linked Immunosorbent Assay | - |
dc.subject.MESH | Erythropoietin/genetics | - |
dc.subject.MESH | Erythropoietin/metabolism | - |
dc.subject.MESH | Erythropoietin/physiology* | - |
dc.subject.MESH | Gene Expression Regulation | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Hypoxia-Inducible Factor 1/genetics | - |
dc.subject.MESH | Hypoxia-Inducible Factor 1/metabolism | - |
dc.subject.MESH | Hypoxia-Inducible Factor 1/physiology* | - |
dc.subject.MESH | Insulin-Like Growth Factor I/pharmacology* | - |
dc.subject.MESH | RNA, Messenger/genetics | - |
dc.subject.MESH | RNA, Messenger/metabolism | - |
dc.subject.MESH | Receptors, Erythropoietin/genetics | - |
dc.subject.MESH | Receptors, Erythropoietin/immunology | - |
dc.subject.MESH | Receptors, Erythropoietin/metabolism | - |
dc.subject.MESH | Reverse Transcriptase Polymerase Chain Reaction | - |
dc.subject.MESH | Transcriptional Activation | - |
dc.title | Autocrine function of erythropoietin in IGF-1-induced erythropoietin biosynthesis | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Pharmacology (약리학) | - |
dc.contributor.googleauthor | Insook Kim | - |
dc.contributor.googleauthor | Chul Hoon Kim | - |
dc.contributor.googleauthor | Yeong Shin Yim | - |
dc.contributor.googleauthor | Young Soo Ahn | - |
dc.identifier.doi | 10.1097/WNR.0b013e32831743fb | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A01057 | - |
dc.contributor.localId | A02246 | - |
dc.relation.journalcode | J02361 | - |
dc.identifier.eissn | 1473-558X | - |
dc.identifier.pmid | 18841090 | - |
dc.identifier.url | http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&AN=00001756-200811190-00010&LSLINK=80&D=ovft | - |
dc.subject.keyword | astrocytes | - |
dc.subject.keyword | erythropoietin | - |
dc.subject.keyword | hypoxia-inducible factor-1 | - |
dc.subject.keyword | insulin-like growth factor-1 | - |
dc.contributor.alternativeName | Kim, Chul Hoon | - |
dc.contributor.alternativeName | Ahn, Young Soo | - |
dc.contributor.affiliatedAuthor | Kim, Chul Hoon | - |
dc.contributor.affiliatedAuthor | Ahn, Young Soo | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 19 | - |
dc.citation.number | 17 | - |
dc.citation.startPage | 1699 | - |
dc.citation.endPage | 1703 | - |
dc.identifier.bibliographicCitation | NEUROREPORT, Vol.19(17) : 1699-1703, 2008 | - |
dc.identifier.rimsid | 34679 | - |
dc.type.rims | ART | - |
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