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척수손상 쥐에서 인간 배아 줄기세포의 이식이 기능적 회복에 미치는 효과

Other Titles
 Effects of Transplantation of Human Embryonic Stem Cells on Functional Recovery in Spinal Cord Injured Rats 
Authors
 정광익  ;  박창일  ;  신지철  ;  박은숙 
Citation
 Journal of the Korean Academy of Rehabilitation Medicine (대한재활의학회지), Vol.32(5) : 491-500, 2008 
Journal Title
 Journal of the Korean Academy of Rehabilitation Medicine (대한재활의학회지) 
ISSN
 1225-584X 
Issue Date
2008
Keywords
Spinal cord injury ; Human embryonic stem cells ; Transplantation ; Functional recovery
Abstract
Objective: To investigate the functional recovery following the transplantation of human embryonic stem (hES) cells into an injured rat spinal cord. Method: Sprague-Dawley rats were subjected to the spinal cord injury (SCI) using the New York University impactor. The rats were randomly allocated into three groups of 12 rats each, one media-treated and two hES cell-transplanted groups (5×103/5Ռl, 2×104/5Ռl). The hES cells were transplanted 1 week after a SCI. Results: The hES cells transplanted into the rats were found to promote the hind limb performance 8 weeks after transplantation. In the electrophysiological study, the transplanted rats showed significantly shortened latencies and increased amplitudes of motor and somatosensory evoked potentials, compared to the media-treated rats. In the spinal cord of the hES cell-treated group, the pathological findings including the glial scar formation and degenerative changes were attenuated and the human Tau protein-positive cells were identified in the vicinity of the necrotic cavity and in the white matter. Conclusion: These results suggest that the transplantation of hES cells might play a role in promoting the functional recovery after a SCI.
Files in This Item:
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Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Rehabilitation Medicine (재활의학교실) > 1. Journal Papers
Yonsei Authors
Park, Eun Sook(박은숙) ORCID logo https://orcid.org/0000-0002-9144-3063
Park, Chang Il(박창일)
Shin, Ji Cheol(신지철) ORCID logo https://orcid.org/0000-0002-1133-1361
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/107772
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