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척수손상 쥐에서 인간 배아 줄기세포의 이식이 기능적 회복에 미치는 효과
DC Field | Value | Language |
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dc.contributor.author | 박은숙 | - |
dc.contributor.author | 박창일 | - |
dc.contributor.author | 신지철 | - |
dc.date.accessioned | 2015-05-19T17:14:30Z | - |
dc.date.available | 2015-05-19T17:14:30Z | - |
dc.date.issued | 2008 | - |
dc.identifier.issn | 1225-584X | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/107772 | - |
dc.description.abstract | Objective: To investigate the functional recovery following the transplantation of human embryonic stem (hES) cells into an injured rat spinal cord. Method: Sprague-Dawley rats were subjected to the spinal cord injury (SCI) using the New York University impactor. The rats were randomly allocated into three groups of 12 rats each, one media-treated and two hES cell-transplanted groups (5×103/5Ռl, 2×104/5Ռl). The hES cells were transplanted 1 week after a SCI. Results: The hES cells transplanted into the rats were found to promote the hind limb performance 8 weeks after transplantation. In the electrophysiological study, the transplanted rats showed significantly shortened latencies and increased amplitudes of motor and somatosensory evoked potentials, compared to the media-treated rats. In the spinal cord of the hES cell-treated group, the pathological findings including the glial scar formation and degenerative changes were attenuated and the human Tau protein-positive cells were identified in the vicinity of the necrotic cavity and in the white matter. Conclusion: These results suggest that the transplantation of hES cells might play a role in promoting the functional recovery after a SCI. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 491~500 | - |
dc.relation.isPartOf | Journal of the Korean Academy of Rehabilitation Medicine (대한재활의학회지) | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | 척수손상 쥐에서 인간 배아 줄기세포의 이식이 기능적 회복에 미치는 효과 | - |
dc.title.alternative | Effects of Transplantation of Human Embryonic Stem Cells on Functional Recovery in Spinal Cord Injured Rats | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Rehabilitation Medicine (재활의학) | - |
dc.contributor.googleauthor | 정광익 | - |
dc.contributor.googleauthor | 박창일 | - |
dc.contributor.googleauthor | 신지철 | - |
dc.contributor.googleauthor | 박은숙 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A01611 | - |
dc.contributor.localId | A01717 | - |
dc.contributor.localId | A02162 | - |
dc.relation.journalcode | J01803 | - |
dc.identifier.pmid | Spinal cord injury; Human embryonic stem cells; Transplantation; Functional recovery | - |
dc.subject.keyword | Spinal cord injury | - |
dc.subject.keyword | Human embryonic stem cells | - |
dc.subject.keyword | Transplantation | - |
dc.subject.keyword | Functional recovery | - |
dc.contributor.alternativeName | Park, Eun Sook | - |
dc.contributor.alternativeName | Park, Chang Il | - |
dc.contributor.alternativeName | Shin, Ji Cheol | - |
dc.contributor.affiliatedAuthor | Park, Eun Sook | - |
dc.contributor.affiliatedAuthor | Park, Chang Il | - |
dc.contributor.affiliatedAuthor | Shin, Ji Cheol | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 32 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 491 | - |
dc.citation.endPage | 500 | - |
dc.identifier.bibliographicCitation | Journal of the Korean Academy of Rehabilitation Medicine (대한재활의학회지), Vol.32(5) : 491-500, 2008 | - |
dc.identifier.rimsid | 34672 | - |
dc.type.rims | ART | - |
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