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Prostate cancer: Added value of subtraction dynamic imaging in 3T magnetic resonance imaging with a phased-array body coil

 Jeong-Sik Yu  ;  Jae-Joon Chung  ;  Soon Won Hong  ;  Byung Ha Chung  ;  Joo Hee Kim  ;  Ki Whang Kim 
 YONSEI MEDICAL JOURNAL, Vol.49(5) : 765-774, 2008 
Journal Title
Issue Date
Aged ; Humans ; Magnetic Resonance Imaging/methods* ; Male ; Middle Aged ; Prostate/pathology ; Prostatic Neoplasms/diagnosis* ; Prostatic Neoplasms/pathology ; Retrospective Studies ; Sensitivity and Specificity
Prostate ; prostate cancer ; magnetic resonance imaging ; subtraction imaging ; dynamic imaging
PURPOSE: To determine the added value of dynamic subtraction magnetic resonance (MR) imaging for the localization of prostate cancer. MATERIALS AND METHODS: We examined 21 consecutive patients who underwent MR imaging in 3T unit with a phased-array body coil and then had radical prostatectomy. After T2-weighted fast spin-echo imaging, we performed a contrast-enhanced dynamic 3D gradient-echo imaging consisting of pre-contrast, 2 successive early-phased (first imaging was started just after the appearance of contrast material in the aortic bifurcation followed by second imaging 35 seconds after the initiation of first imaging) and one 5-minute delayed post-contrast series. Subtraction of pre- contrast images from corresponding post-contrast images of each phase was performed on the console. RESULTS: On ROC analysis, the overall accuracy (Az value) of dynamic imaging combined with subtraction imaging was higher than T2-weighted imaging (p = 0.001) or conventional dynamic imaging alone (p = 0.074) for localization of cancer foci regardless of their zonal locations. Among pathologically verified 81 lesions, the mean volume of detected lesions with the subtraction images (n = 49, 0.69cm3) was smaller than with T2-weighted images (n = 14, 1.05cm3) or conventional dynamic images (n = 43, 0.71cm3). CONCLUSION: For localization of small prostate cancer, additional subtraction for the dynamic imaging could be superior to both T2-weighted imaging and un-subtracted dynamic imaging.
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1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Urology (비뇨의학교실) > 1. Journal Papers
Yonsei Authors
Kim, Ki Whang(김기황)
Kim, Joo Hee(김주희) ORCID logo https://orcid.org/0000-0001-5383-3602
Yu, Jeong Sik(유정식) ORCID logo https://orcid.org/0000-0002-8171-5838
Chung, Byung Ha(정병하) ORCID logo https://orcid.org/0000-0001-9817-3660
Chung, Jae Joon(정재준) ORCID logo https://orcid.org/0000-0002-7447-1193
Hong, Soon Won(홍순원) ORCID logo https://orcid.org/0000-0002-0324-2414
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