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만성 신질환 환자에서 여러 가지 사구체 여과율 산출 방법간의 비교

Other Titles
 Comparison of Various Methods for Estimating Glomerular Filtration Rate in Patients with Chronic Kidney Disease 
Authors
 김동현  ;  강신욱  ;  고광일  ;  김찬호  ;  이주현  ;  이진하  ;  김은영  ;  박정탁  ;  장태익  ;  김현욱  ;  박선영  ;  장제현  ;  김동기  ;  유태현  ;  한대석 
Citation
 Korean Journal of Nephrology, Vol.27(5) : 560-568, 2008 
Journal Title
 Korean Journal of Nephrology 
ISSN
 1975-9460 
Issue Date
2008
Keywords
Glomerular filtration rate
Abstract
PURPOSE: Several methods are used to estimate glomerular filtration rate (GFR), but there are limitations in each method. We investigated the variation in GFR measured by different methods in patients with chronic kidney disease (CKD). METHODS: 549 patients with CKD stages 2-5, who underwent creatinine clearance (Ccr) and (99m)Tc-DTPA renal scan, were enrolled. GFR was calculated by using Cockcroft-Gault equation (CG-GFR) and MDRD equation (MDRD-GFR). The correlations between MDRD-GFR and GFR estimated by other methods were analyzed according to CKD stages and age groups (<40, 40-59, and > or = 60 years). RESULTS: The mean age of patients was 55+/-19 year (male 60%). CG-GFR, Ccr, and estimated GFR by (99m)Tc-DTPA renal scan (DTPA-GFR) correlated significantly with MDRD-GFR in all CKD stages and all age groups (p<0.01). Compared to patients with stages 2-4 CKD, however, the possibilities of CGGFR, Ccr, and DTPA-GFR to be within 30% of MDRD-GFR were significantly lower in stage 5 CKD patients (p<0.05). In addition, the ratio of DTPA-GFR/MDRD-GFR in stage 5 CKD patients was 2.24+/-1.40, indicating overestimation of DTPA-GFR in these patients. On the other hand, the accuracy of various GFR-estimating methods was higher in patients aged more than 60 years compared to the others. CONCLUSION: CG-GFR, Ccr, and DTPA-GFR correlated significantly with MDRD-GFR, but there was a wide variation in GFR estimated by various methods. Therefore, a careful interpretation of estimation in GFR is needed according to the stage of CKD and the age of patients.
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Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
7. Others (기타) > Dept. of Health Promotion (건강의학과) > 1. Journal Papers
Yonsei Authors
Kang, Shin Wook(강신욱) ORCID logo https://orcid.org/0000-0002-5677-4756
Ko, Kwang Il(고광일)
Kim, Dong Ki(김동기)
Kim, Dong Hyun(김동현)
Kim, Chan Ho(김찬호)
Kim, Hyun Wook(김현욱) ORCID logo https://orcid.org/0000-0002-4274-7562
Park, Sun Young(박선영)
Park, Jung Tak(박정탁) ORCID logo https://orcid.org/0000-0002-2325-8982
Yoo, Tae Hyun(유태현) ORCID logo https://orcid.org/0000-0002-9183-4507
Lee, Jin Ha(이진하)
Chang, Jae Hyun(장제현)
Chang, Tae Ik(장태익)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/107606
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