4 275

Cited 75 times in

Number of metastatic lymph nodes in resected non-small cell lung cancer predicts patient survival

Authors
 Jin Gu Lee  ;  Chang Young Lee  ;  In Kyu Park  ;  Dae Joon Kim  ;  Seong Yong Park  ;  Kil Dong Kim  ;  Kyung Young Chung 
Citation
 ANNALS OF THORACIC SURGERY, Vol.85(1) : 211-215, 2008 
Journal Title
 ANNALS OF THORACIC SURGERY 
ISSN
 0003-4975 
Issue Date
2008
MeSH
Aged ; Aged, 80 and over ; Biopsy, Needle ; Carcinoma, Non-Small-Cell Lung/mortality* ; Carcinoma, Non-Small-Cell Lung/secondary* ; Carcinoma, Non-Small-Cell Lung/surgery ; Cohort Studies ; Confidence Intervals ; Female ; Humans ; Lung Neoplasms/mortality* ; Lung Neoplasms/pathology ; Lung Neoplasms/surgery* ; Lymph Node Excision/statistics & numerical data* ; Lymph Nodes/pathology* ; Lymph Nodes/surgery ; Lymphatic Metastasis ; Male ; Middle Aged ; Neoplasm Staging ; Pneumonectomy/methods ; Predictive Value of Tests ; Probability ; Prognosis ; Proportional Hazards Models ; Retrospective Studies ; Risk Assessment ; Survival Analysis ; Treatment Outcome
Keywords
Aged ; Aged, 80 and over ; Biopsy, Needle ; Carcinoma, Non-Small-Cell Lung/mortality* ; Carcinoma, Non-Small-Cell Lung/secondary* ; Carcinoma, Non-Small-Cell Lung/surgery ; Cohort Studies ; Confidence Intervals ; Female ; Humans ; Lung Neoplasms/mortality* ; Lung Neoplasms/pathology ; Lung Neoplasms/surgery* ; Lymph Node Excision/statistics & numerical data* ; Lymph Nodes/pathology* ; Lymph Nodes/surgery ; Lymphatic Metastasis ; Male ; Middle Aged ; Neoplasm Staging ; Pneumonectomy/methods ; Predictive Value of Tests ; Probability ; Prognosis ; Proportional Hazards Models ; Retrospective Studies ; Risk Assessment ; Survival Analysis ; Treatment Outcome
Abstract
BACKGROUND: This study was conducted to evaluate the prognostic significance of the number of lymph node metastases compared with the pathologic nodal stage (pN category) based on the anatomic extent of lymph node metastases in TNM classification of non-small cell lung cancer. METHODS: We reviewed 1,081 patients who underwent major pulmonary resection and were proven to be pathologic stage I through IIIA between 1990 and 2006. Patients were divided into four subgroups (nN category) according to the number of metastatic lymph nodes: those without nodal metastases were nN0, those with 1 to 3 metastatic lymph nodes were nN1-3, those with 4 to 14 were nN4-14, and those with 15 or more were nN > or = 15. RESULTS: The nN category followed a significant stepwise deterioration. The 5-year survival rate was 69.0% for nN0, 42.9% for nN1-3, 30.0% for nN4-14, and 11.5% for nN > or = 15 (p < 0.001). Multivariate analysis showed that the nN category was a significant prognostic indicator similar to the pN category. Hazard ratios versus pN0 for pN1 and pN2 were 1.639 and 2.639, respectively, and 1.860, 2.029, and 4.758 for nN1-3, nN4-14, and nN > or = 15, respectively. The nN category showed excellent agreement with the pN category (kappa = 0.723; p < 0.001). CONCLUSIONS: We can predict patient prognosis after surgery for non-small cell lung cancer according to the number of lymph nodes instead of the anatomic extent of lymph node metastases. At minimum, the number of metastatic lymph nodes adds more information to the pN category of the current TNM classification system.
Full Text
http://www.sciencedirect.com/science/article/pii/S0003497507016748
DOI
10.1016/j.athoracsur.2007.08.020
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Thoracic and Cardiovascular Surgery (흉부외과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Dae Joon(김대준)
Park, In Kyu(박인규)
Lee, Jin Gu(이진구)
Lee, Chang Young(이창영)
Chung, Kyung Young(정경영)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/107530
사서에게 알리기
  feedback

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse