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Number of metastatic lymph nodes in resected non-small cell lung cancer predicts patient survival

DC Field Value Language
dc.contributor.author이진구-
dc.contributor.author이창영-
dc.contributor.author정경영-
dc.contributor.author김대준-
dc.contributor.author박인규-
dc.date.accessioned2015-05-19T17:06:55Z-
dc.date.available2015-05-19T17:06:55Z-
dc.date.issued2008-
dc.identifier.issn0003-4975-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/107530-
dc.description.abstractBACKGROUND: This study was conducted to evaluate the prognostic significance of the number of lymph node metastases compared with the pathologic nodal stage (pN category) based on the anatomic extent of lymph node metastases in TNM classification of non-small cell lung cancer. METHODS: We reviewed 1,081 patients who underwent major pulmonary resection and were proven to be pathologic stage I through IIIA between 1990 and 2006. Patients were divided into four subgroups (nN category) according to the number of metastatic lymph nodes: those without nodal metastases were nN0, those with 1 to 3 metastatic lymph nodes were nN1-3, those with 4 to 14 were nN4-14, and those with 15 or more were nN > or = 15. RESULTS: The nN category followed a significant stepwise deterioration. The 5-year survival rate was 69.0% for nN0, 42.9% for nN1-3, 30.0% for nN4-14, and 11.5% for nN > or = 15 (p < 0.001). Multivariate analysis showed that the nN category was a significant prognostic indicator similar to the pN category. Hazard ratios versus pN0 for pN1 and pN2 were 1.639 and 2.639, respectively, and 1.860, 2.029, and 4.758 for nN1-3, nN4-14, and nN > or = 15, respectively. The nN category showed excellent agreement with the pN category (kappa = 0.723; p < 0.001). CONCLUSIONS: We can predict patient prognosis after surgery for non-small cell lung cancer according to the number of lymph nodes instead of the anatomic extent of lymph node metastases. At minimum, the number of metastatic lymph nodes adds more information to the pN category of the current TNM classification system.-
dc.description.statementOfResponsibilityopen-
dc.format.extent211~215-
dc.relation.isPartOfANNALS OF THORACIC SURGERY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAged-
dc.subject.MESHAged, 80 and over-
dc.subject.MESHBiopsy, Needle-
dc.subject.MESHCarcinoma, Non-Small-Cell Lung/mortality*-
dc.subject.MESHCarcinoma, Non-Small-Cell Lung/secondary*-
dc.subject.MESHCarcinoma, Non-Small-Cell Lung/surgery-
dc.subject.MESHCohort Studies-
dc.subject.MESHConfidence Intervals-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHLung Neoplasms/mortality*-
dc.subject.MESHLung Neoplasms/pathology-
dc.subject.MESHLung Neoplasms/surgery*-
dc.subject.MESHLymph Node Excision/statistics & numerical data*-
dc.subject.MESHLymph Nodes/pathology*-
dc.subject.MESHLymph Nodes/surgery-
dc.subject.MESHLymphatic Metastasis-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHNeoplasm Staging-
dc.subject.MESHPneumonectomy/methods-
dc.subject.MESHPredictive Value of Tests-
dc.subject.MESHProbability-
dc.subject.MESHPrognosis-
dc.subject.MESHProportional Hazards Models-
dc.subject.MESHRetrospective Studies-
dc.subject.MESHRisk Assessment-
dc.subject.MESHSurvival Analysis-
dc.subject.MESHTreatment Outcome-
dc.titleNumber of metastatic lymph nodes in resected non-small cell lung cancer predicts patient survival-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Thoracic & Cardiovascular Surgery (흉부외과학)-
dc.contributor.googleauthorJin Gu Lee-
dc.contributor.googleauthorChang Young Lee-
dc.contributor.googleauthorIn Kyu Park-
dc.contributor.googleauthorDae Joon Kim-
dc.contributor.googleauthorSeong Yong Park-
dc.contributor.googleauthorKil Dong Kim-
dc.contributor.googleauthorKyung Young Chung-
dc.identifier.doi10.1016/j.athoracsur.2007.08.020-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA03225-
dc.contributor.localIdA03245-
dc.contributor.localIdA03571-
dc.contributor.localIdA00368-
dc.contributor.localIdA01625-
dc.relation.journalcodeJ00183-
dc.identifier.eissn1552-6259-
dc.identifier.pmid18154813-
dc.identifier.urlhttp://www.sciencedirect.com/science/article/pii/S0003497507016748-
dc.subject.keywordAged-
dc.subject.keywordAged, 80 and over-
dc.subject.keywordBiopsy, Needle-
dc.subject.keywordCarcinoma, Non-Small-Cell Lung/mortality*-
dc.subject.keywordCarcinoma, Non-Small-Cell Lung/secondary*-
dc.subject.keywordCarcinoma, Non-Small-Cell Lung/surgery-
dc.subject.keywordCohort Studies-
dc.subject.keywordConfidence Intervals-
dc.subject.keywordFemale-
dc.subject.keywordHumans-
dc.subject.keywordLung Neoplasms/mortality*-
dc.subject.keywordLung Neoplasms/pathology-
dc.subject.keywordLung Neoplasms/surgery*-
dc.subject.keywordLymph Node Excision/statistics & numerical data*-
dc.subject.keywordLymph Nodes/pathology*-
dc.subject.keywordLymph Nodes/surgery-
dc.subject.keywordLymphatic Metastasis-
dc.subject.keywordMale-
dc.subject.keywordMiddle Aged-
dc.subject.keywordNeoplasm Staging-
dc.subject.keywordPneumonectomy/methods-
dc.subject.keywordPredictive Value of Tests-
dc.subject.keywordProbability-
dc.subject.keywordPrognosis-
dc.subject.keywordProportional Hazards Models-
dc.subject.keywordRetrospective Studies-
dc.subject.keywordRisk Assessment-
dc.subject.keywordSurvival Analysis-
dc.subject.keywordTreatment Outcome-
dc.contributor.alternativeNameLee, Jin Gu-
dc.contributor.alternativeNameLee, Chang Young-
dc.contributor.alternativeNameChung, Kyung Young-
dc.contributor.alternativeNameKim, Dae Joon-
dc.contributor.alternativeNamePark, In Kyu-
dc.contributor.affiliatedAuthorLee, Jin Gu-
dc.contributor.affiliatedAuthorLee, Chang Young-
dc.contributor.affiliatedAuthorChung, Kyung Young-
dc.contributor.affiliatedAuthorKim, Dae Joon-
dc.contributor.affiliatedAuthorPark, In Kyu-
dc.rights.accessRightsnot free-
dc.citation.volume85-
dc.citation.number1-
dc.citation.startPage211-
dc.citation.endPage215-
dc.identifier.bibliographicCitationANNALS OF THORACIC SURGERY, Vol.85(1) : 211-215, 2008-
dc.identifier.rimsid57269-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Thoracic and Cardiovascular Surgery (흉부외과학교실) > 1. Journal Papers

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