Hypofractionated high-dose intensity-modulated radiotherapy (60 Gy at 2.5 Gy per fraction) for recurrent renal cell carcinoma: A case report

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Authors: Jaeho Cho ; Gwi Eon Kim ; Koon Ho Rha ; Joong Bae Ahn ; Chang Geol Lee ; Chang-Ok Suh ; Jinsil Seong ; Ki Chang Keum ; Song Ie Kim ; Yoon-Hee Lee

MeSH: Carcinoma, Renal Cell/pathology ; Carcinoma, Renal Cell/radiotherapy* ; Dose Fractionation ; Female ; Humans ; Kidney Neoplasms/pathology ; Kidney Neoplasms/radiotherapy* ; Middle Aged ; Neoplasm Recurrence, Local/pathology ; Neoplasm Recurrence, Local/radiotherapy* ; Radiotherapy, Intensity-Modulated

Keywords: Radiotherapy ; Intensity-Modulated ; Carcinoma ; Renal Cell ; Radioresistance

Abstract: A patient with renal cell carcinoma (RCC) developed synchronous bone metastasis with metachronous relapses to the bone and renal fossa. The primary lesion was initially removed surgically, and the metastatic bone lesions and locally recurrent tumours were treated by a high-fractional dose and high-total-dose intensity-modulated radiotherapy (IMRT, 60 Gy at 2.5 Gy per fraction) without significant side effects. All the grossly relapsed tumors underwent complete remission (CR) within a short time after IMRT. To date, CR has been maintained for more than two years. This case study reports the successful treatment of radioresistant RCC using a new scheme that involves a fractionation regimen with a high precision radiotherapy