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Neurally induced umbilical cord blood cells modestly repair injured spinal cords.

Authors
 Sung-Rae Cho  ;  Mal Sook Yang  ;  Sun Hee Yim  ;  in Hee Park  ;  Jong Eun Lee  ;  Young-woo Eom  ;  In Keun Jang  ;  Hyo Eun Kim  ;  Joon Seong Park  ;  Hyun Ok Kim  ;  Bae Hwan Lee  ;  Chang-il Park  ;  Young Jin Kim 
Citation
 NEUROREPORT, Vol.19(13) : 1259-1263, 2008 
Journal Title
 NEUROREPORT 
ISSN
 0959-4965 
Issue Date
2008
MeSH
Animals ; Behavior, Animal/physiology ; Cell Differentiation ; Cells, Cultured ; Cord Blood Stem Cell Transplantation/methods* ; Electrophysiology/methods ; Enzyme-Linked Immunosorbent Assay ; Evoked Potentials, Somatosensory/physiology ; Glial Fibrillary Acidic Protein/genetics ; Glial Fibrillary Acidic Protein/metabolism ; Humans ; Immunohistochemistry ; Male ; Motor Activity/physiology ; Myelin Basic Protein/genetics ; Myelin Basic Protein/metabolism ; Rats ; Rats, Sprague-Dawley ; Recovery of Function/physiology* ; Reverse Transcriptase Polymerase Chain Reaction ; Spinal Cord Injuries/physiopathology ; Spinal Cord Injuries/surgery* ; Stem Cells/cytology ; Stem Cells/metabolism*
Keywords
functional recovery ; multipotent progenitor cells ; neural induction ; spinal cord injury ; umbilical cord blood
Abstract
Umbilical cord blood (UCB) is known to have stem/progenitor cells. We earlier showed that novel progenitors could be isolated from cryopreserved human UCB with high efficiency. The multipotent progenitor cells were induced to differentiate into neural-lineage cells under the appropriate condition. In this study, we confirmed these neurally induced progenitor cells (NPCs), containing higher quantities of nerve growth factor, promoted functional recovery in rats with spinal cord injury (SCI). Sprague-Dawley rats with SCI achieved a modest improvement in locomotor rating scale until 10 weeks after transplantation of the NPCs. SCI rats treated with NPCs also showed somatosensory-evoked potentials were recovered, and grafted cells especially exhibited oligodendrocytic phenotype around the necrotic cavity. These findings suggest that UCB-NPCs might be a therapeutic resource to repair damaged spinal cords.
Full Text
http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&AN=00001756-200808270-00003&LSLINK=80&D=ovft
DOI
10.1097/WNR.0b013e3283089234
Appears in Collections:
1. College of Medicine (의과대학) > Medical Research Center (임상의학연구센터) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Medical Engineering (의학공학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Physiology (생리학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Rehabilitation Medicine (재활의학교실) > 1. Journal Papers
Yonsei Authors
Kim, Hyun Ok(김현옥) ORCID logo https://orcid.org/0000-0002-4964-1963
Kim, Hyo Eun(김효은)
Park, Chang Il(박창일)
Lee, Bae Hwan(이배환) ORCID logo https://orcid.org/0000-0003-4719-9021
Lee, Jong Eun(이종은)
Cho, Sung-Rae(조성래) ORCID logo https://orcid.org/0000-0003-1429-2684
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/107122
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