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Effects of target concentration infusion of propofol and tracheal intubation on QTc interval

Authors
 D. H. Kim  ;  T. D. Kweon  ;  S. B. Nam  ;  D. W. Han  ;  W. Y. Cho  ;  J. S. Lee 
Citation
 ANAESTHESIA, Vol.63(10) : 1061-1064, 2008 
Journal Title
 ANAESTHESIA 
ISSN
 0003-2409 
Issue Date
2008
MeSH
Adult ; Anesthetics, Intravenous/administration & dosage ; Anesthetics, Intravenous/adverse effects* ; Blood Pressure/drug effects ; Heart Rate/drug effects ; Humans ; Infusions, Intravenous ; Intubation, Intratracheal/adverse effects* ; Long QT Syndrome/chemically induced ; Long QT Syndrome/etiology* ; Middle Aged ; Monitoring, Intraoperative/methods ; Propofol/administration & dosage ; Propofol/adverse effects*
Keywords
Adult ; Anesthetics, Intravenous/administration & dosage ; Anesthetics, Intravenous/adverse effects* ; Blood Pressure/drug effects ; Heart Rate/drug effects ; Humans ; Infusions, Intravenous ; Intubation, Intratracheal/adverse effects* ; Long QT Syndrome/chemically induced ; Long QT Syndrome/etiology* ; Middle Aged ; Monitoring, Intraoperative/methods ; Propofol/administration & dosage ; Propofol/adverse effects*
Abstract
This study was designed to evaluate the effect of target controlled infusion of propofol on QTc interval and tracheal intubation. Twenty-five unpremedicated, ASA class I or II patients were selected and target concentration infusion of propofol at 5 microg x ml(-1) was used throughout the study. The QTc interval was measured before anaesthetic induction (baseline, T1), 10 min after propofol infusion (T2), immediately after tracheal intubation (T3), and 1 min after tracheal intubation (T4). The QTc interval increased significantly at 10 min after the propofol infusion started compared to baseline (p = 0.003). After tracheal intubation, the QTc interval was further increased when compared to that at T2 (p < 0.0001). The increased QTc interval was within normal limit and no patient had an arrhythmia. In conclusion, although statistically significant, the increase in QTc interval was too small to be clinically significant during propofol infusion. However, the combination of propofol and tracheal intubation must be used carefully in patients with prolonged QTc interval.
Full Text
http://onlinelibrary.wiley.com/doi/10.1111/j.1365-2044.2008.05564.x/abstract
DOI
10.1111/j.1365-2044.2008.05564.x
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Anesthesiology and Pain Medicine (마취통증의학교실) > 1. Journal Papers
Yonsei Authors
Kweon, Tae Dong(권태동) ORCID logo https://orcid.org/0000-0002-5451-1856
Kim, Do Hyeong(김도형) ORCID logo https://orcid.org/0000-0003-2018-8090
Nam, Sang Beom(남상범) ORCID logo https://orcid.org/0000-0002-9704-1866
Lee, Jong Seok(이종석) ORCID logo https://orcid.org/0000-0002-7945-2530
Han, Dong Woo(한동우) ORCID logo https://orcid.org/0000-0002-8757-663X
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/107097
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