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Effects of target concentration infusion of propofol and tracheal intubation on QTc interval

DC FieldValueLanguage
dc.contributor.author권태동-
dc.contributor.author남상범-
dc.contributor.author이종석-
dc.contributor.author한동우-
dc.date.accessioned2015-05-19T16:52:19Z-
dc.date.available2015-05-19T16:52:19Z-
dc.date.issued2008-
dc.identifier.issn0003-2409-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/107097-
dc.description.abstractThis study was designed to evaluate the effect of target controlled infusion of propofol on QTc interval and tracheal intubation. Twenty-five unpremedicated, ASA class I or II patients were selected and target concentration infusion of propofol at 5 microg x ml(-1) was used throughout the study. The QTc interval was measured before anaesthetic induction (baseline, T1), 10 min after propofol infusion (T2), immediately after tracheal intubation (T3), and 1 min after tracheal intubation (T4). The QTc interval increased significantly at 10 min after the propofol infusion started compared to baseline (p = 0.003). After tracheal intubation, the QTc interval was further increased when compared to that at T2 (p < 0.0001). The increased QTc interval was within normal limit and no patient had an arrhythmia. In conclusion, although statistically significant, the increase in QTc interval was too small to be clinically significant during propofol infusion. However, the combination of propofol and tracheal intubation must be used carefully in patients with prolonged QTc interval.-
dc.description.statementOfResponsibilityopen-
dc.format.extent1061~1064-
dc.relation.isPartOfANAESTHESIA-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdult-
dc.subject.MESHAnesthetics, Intravenous/administration & dosage-
dc.subject.MESHAnesthetics, Intravenous/adverse effects*-
dc.subject.MESHBlood Pressure/drug effects-
dc.subject.MESHHeart Rate/drug effects-
dc.subject.MESHHumans-
dc.subject.MESHInfusions, Intravenous-
dc.subject.MESHIntubation, Intratracheal/adverse effects*-
dc.subject.MESHLong QT Syndrome/chemically induced-
dc.subject.MESHLong QT Syndrome/etiology*-
dc.subject.MESHMiddle Aged-
dc.subject.MESHMonitoring, Intraoperative/methods-
dc.subject.MESHPropofol/administration & dosage-
dc.subject.MESHPropofol/adverse effects*-
dc.titleEffects of target concentration infusion of propofol and tracheal intubation on QTc interval-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Anesthesiology (마취통증의학)-
dc.contributor.googleauthorD. H. Kim-
dc.contributor.googleauthorT. D. Kweon-
dc.contributor.googleauthorS. B. Nam-
dc.contributor.googleauthorD. W. Han-
dc.contributor.googleauthorW. Y. Cho-
dc.contributor.googleauthorJ. S. Lee-
dc.identifier.doi10.1111/j.1365-2044.2008.05564.x-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00255-
dc.contributor.localIdA01253-
dc.contributor.localIdA04274-
dc.contributor.localIdA03141-
dc.contributor.localIdA00390-
dc.relation.journalcodeJ00128-
dc.identifier.eissn1365-2044-
dc.identifier.pmid18717665-
dc.identifier.urlhttp://onlinelibrary.wiley.com/doi/10.1111/j.1365-2044.2008.05564.x/abstract-
dc.subject.keywordAdult-
dc.subject.keywordAnesthetics, Intravenous/administration & dosage-
dc.subject.keywordAnesthetics, Intravenous/adverse effects*-
dc.subject.keywordBlood Pressure/drug effects-
dc.subject.keywordHeart Rate/drug effects-
dc.subject.keywordHumans-
dc.subject.keywordInfusions, Intravenous-
dc.subject.keywordIntubation, Intratracheal/adverse effects*-
dc.subject.keywordLong QT Syndrome/chemically induced-
dc.subject.keywordLong QT Syndrome/etiology*-
dc.subject.keywordMiddle Aged-
dc.subject.keywordMonitoring, Intraoperative/methods-
dc.subject.keywordPropofol/administration & dosage-
dc.subject.keywordPropofol/adverse effects*-
dc.contributor.alternativeNameKweon, Tae Dong-
dc.contributor.alternativeNameNam, Sang Beom-
dc.contributor.alternativeNameLee, Jong Seok-
dc.contributor.alternativeNameHan, Dong Woo-
dc.contributor.affiliatedAuthorKweon, Tae Dong-
dc.contributor.affiliatedAuthorNam, Sang Beom-
dc.contributor.affiliatedAuthorHan, Dong Woo-
dc.contributor.affiliatedAuthorLee, Jong Seok-
dc.rights.accessRightsnot free-
dc.citation.volume63-
dc.citation.number10-
dc.citation.startPage1061-
dc.citation.endPage1064-
dc.identifier.bibliographicCitationANAESTHESIA, Vol.63(10) : 1061-1064, 2008-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Anesthesiology and Pain Medicine (마취통증의학교실) > 1. Journal Papers

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