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Clinical characteristics and outcome for hepatitis C virus-positive diffuse large B-cell lymphoma

Authors
 BYEONG-BAE PARK  ;  JIN SEOK KIM  ;  YOUNG-YUEL LEE  ;  HYE JIN KANG  ;  BAEK YEOL RYOO  ;  JUNG HUN KANG  ;  HO YOUNG KIM  ;  BONG-SEOG KIM  ;  SUNG YONG OH  ;  HYUK CHAN KWON  ;  JONG HO WON  ;  KIHYUN KIM  ;  KEUNCHIL PARK  ;  CHEOLWON SUH  ;  WON SEOG KIM 
Citation
 LEUKEMIA & LYMPHOMA, Vol.49(1) : 88-94, 2008 
Journal Title
 LEUKEMIA & LYMPHOMA 
ISSN
 1042-8194 
Issue Date
2008
MeSH
Adult ; Age Factors ; Aged ; Aged, 80 and over ; Female ; Hepacivirus* ; Humans ; Korea ; Lymphoma, Large B-Cell, Diffuse/epidemiology ; Lymphoma, Large B-Cell, Diffuse/mortality ; Lymphoma, Large B-Cell, Diffuse/virology* ; Male ; Middle Aged ; Remission Induction ; Retrospective Studies ; Survival Analysis ; Treatment Outcome
Keywords
Hepatitis C virus ; diffuse large B-cell lymphoma ; clinical outcome
Abstract
Several previous studies have addressed the association between hepatitis C virus (HCV) infection and non-Hodgkin lymphoma (NHL), but there are few studies on HCV-related diffuse large B-cell lymphoma (DLBL). We conducted this retrospective study to investigate the distinctive clinical characteristics and outcome for HCV-positive DLBL. We compared the clinical characteristics and outcomes of 32 HCV-positive DLBL cases from nine Korean institutions with those of 371 HCV-negative DLBL cases. A higher percentage of HCV-positive DLBL cases were associated with old age (> or = 60) than HCV-negative DLBL cases at diagnosis (59.4% vs. 36.1%, respectively, P = 0.009) and HCV-positive cases were less likely than HCV-negative cases to have extranodal involvement (53.1% vs. 71.1%, respectively, P = 0.044). The nodal presentation was the only independent factor favorably influencing the event free survival (EFS) in HCV-positive DLBL (HR = 0.11, 95% CI; 0.01-0.95, P = 0.012). In comparison to patients with HCV-negative DLBL, HCV-positive DLBL patients had a superior complete response rate (P = 0.023) and EFS (P = 0.02). In Korean patients, HCV-positive DLBL is more common with old age and has less extranodal involvement than does HCV-negative DLBL. The superior survival outcome for HCV-positive DLBL should be verified by further investigation, especially with respect to its correlation with transformed low-grade NHL
Full Text
http://informahealthcare.com/doi/abs/10.1080/10428190701732861
DOI
10.1080/10428190701732861
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Jin Seok(김진석) ORCID logo https://orcid.org/0000-0001-8986-8436
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/107051
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