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Biologically based treatment of immature permanent teeth with pulpal necrosis: a case series

Authors
 Il-Young Jung  ;  Seung-Jong Lee  ;  Kenneth M. Hargreaves 
Citation
 Journal of Endodontics, Vol.34(7) : 876-887, 2008 
Journal Title
 Journal of Endodontics 
ISSN
 0099-2399 
Issue Date
2008
MeSH
Adolescent ; Anti-Infective Agents, Local/therapeutic use* ; Child ; Ciprofloxacin ; Dens in Dente/therapy ; Dental Pulp/blood supply* ; Dental Pulp Necrosis/drug therapy* ; Dentition, Permanent ; Female ; Humans ; Male ; Metronidazole ; Minocycline ; Neovascularization, Physiologic* ; Periapical Periodontitis/drug therapy ; Regeneration ; Root Canal Irrigants/therapeutic use* ; Sodium Hypochlorite ; Tooth Apex/growth & development*
Keywords
Endodontics ; immature permanent tooth ; open apex ; regenerative ; revascularization ; stem cell
Abstract
This case series reports the outcomes of 8 patients (ages 9-14 years) who presented with 9 immature permanent teeth with pulpal necrosis and apical periodontitis. During treatment, 5 of the teeth were found to have at least some residual vital tissue remaining in the root canal systems. After NaOCl irrigation and medication with ciprofloxacin, metronidazole, and minocycline, these teeth were sealed with mineral trioxide aggregate and restored. The other group of 4 teeth had no evidence of any residual vital pulp tissue. This second group of teeth was treated with NaOCl irrigation and medicated with ciprofloxacin, metronidazole, and minocycline followed by a revascularization procedure adopted from the trauma literature (bleeding evoked to form an intracanal blood clot). In both groups of patients, there was evidence of satisfactory postoperative clinical outcomes (1-5 years); the patients were asymptomatic, no sinus tracts were evident, apical periodontitis was resolved, and there was radiographic evidence of continuing thickness of dentinal walls, apical closure, or increased root length.
Full Text
http://www.sciencedirect.com/science/article/pii/S0099239908002768
DOI
10.1016/j.joen.2008.03.023
Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Conservative Dentistry (보존과학교실) > 1. Journal Papers
Yonsei Authors
Lee, Seung Jong(이승종)
Jung, Il Young(정일영) ORCID logo https://orcid.org/0000-0001-8972-2664
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/107004
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