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Factors influencing pathologic results after total mesorectal excision for rectal cancer: analysis of consecutive 100 cases

Authors
 Seung Hyuk Baik  ;  Nam Kyu Kim  ;  Kang Young Lee  ;  Seung Kook Sohn  ;  Chang Hwan Cho  ;  Myeong Jin Kim  ;  Hogeun Kim  ;  Rina K Shinn 
Citation
 ANNALS OF SURGICAL ONCOLOGY, Vol.15(3) : 721-728, 2008 
Journal Title
 ANNALS OF SURGICAL ONCOLOGY 
ISSN
 1068-9265 
Issue Date
2008
MeSH
Adult ; Aged ; Aged, 80 and over ; Combined Modality Therapy ; Female ; Humans ; Male ; Middle Aged ; Pelvimetry ; Pelvis/anatomy & histology* ; Prospective Studies ; Rectal Neoplasms/pathology* ; Rectal Neoplasms/surgery* ; Rectal Neoplasms/therapy
Keywords
Rectal cancer ; Total mesorectal excision ; Quality of the mesorectum ; Circumferential resection margin
Abstract
BACKGROUND: The aim of this study was to analyze clinical and anatomical factors affecting the pathologic quality of the resected specimen after total mesorectal excision (TME) for rectal cancer. METHODS: A total of 100 patients who underwent TME for mid or low rectal cancer were evaluated prospectively. MRI pelvimetry data (transverse diameter, obstetric conjugate, interspinous distance, sacrum length, and sacrum depth) were analyzed as anatomically affecting factors to postoperative specimen quality. Sex, body mass index (BMI), type of surgery, tumor size, and tumor distance from the anal verge were analyzed as clinically affecting factors. The gross judgment of resected specimen, circumferential resection margin and the number of harvested lymph nodes were used to access postoperative specimen quality. RESULTS: The univariate and multivariate analysis showed that narrow obstetric conjugate and shorter interspinous distance were related to the inadequate quality of the mesorectum in the specimen (P = 0.022, P = 0.030). Interspinous distance was a predicting factor of a positive circumferential resection margin (P = 0.007). There were no clinical factors affecting the inadequate quality of the mesorectum or positive circumferential resection margin. Moreover, there were no clinico-anatomical factors affecting the number of harvested lymph nodes after TME. CONCLUSION: Narrow obstetric conjugate and shorter interspinous distance were factors leading to poor postoperative specimen quality. Rectal cancer patients with narrow obstetric conjugate or shorter interspinous distance should be considered as high-risk patients with regard to specimen quality, which is in turn related to oncological outcome.
Full Text
http://link.springer.com/article/10.1245/s10434-007-9706-z
DOI
10.1245/s10434-007-9706-z
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
Yonsei Authors
Kim, Nam Kyu(김남규) ORCID logo https://orcid.org/0000-0003-0639-5632
Kim, Myeong Jin(김명진) ORCID logo https://orcid.org/0000-0001-7949-5402
Baik, Seung Hyuk(백승혁) ORCID logo https://orcid.org/0000-0003-4183-2332
Sohn, Seung Kook(손승국)
Lee, Kang Young(이강영)
Cho, Chang Hwan(조장환)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/107003
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