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Glomerular glucocorticoid receptor expression is reduced in late responders to steroids in adult-onset minimal change disease

Authors
 Seung Hyeok Han  ;  Sun Young Park  ;  Jin-Ji Li  ;  Seung Jae Kwak  ;  Dong Sub Jung  ;  Hoon Young Choi  ;  Jung Eun Lee  ;  Sung Jin Moon  ;  Dong Ki Kim  ;  Dae-Suk Han  ;  Shin-Wook Kang 
Citation
 NEPHROLOGY DIALYSIS TRANSPLANTATION, Vol.23(1) : 169-175, 2008 
Journal Title
 NEPHROLOGY DIALYSIS TRANSPLANTATION 
ISSN
 0931-0509 
Issue Date
2008
MeSH
Adult ; Age Factors ; Female ; Glucocorticoids/therapeutic use* ; Humans ; Kidney Glomerulus/drug effects* ; Kidney Glomerulus/metabolism* ; Male ; Nephrosis, Lipoid/drug therapy* ; Prednisolone/therapeutic use* ; Receptors, Glucocorticoid/biosynthesis* ; Time Factors
Keywords
Adult ; Age Factors ; Female ; Glucocorticoids/therapeutic use* ; Humans ; Kidney Glomerulus/drug effects* ; Kidney Glomerulus/metabolism* ; Male ; Nephrosis, Lipoid/drug therapy* ; Prednisolone/therapeutic use* ; Receptors, Glucocorticoid/biosynthesis* ; Time Factors
Abstract
BACKGROUND: Compared to children, adult patients with minimal change disease (MCD) tend to have a slower response to steroids, but little is known about the factors influencing the steroid responsiveness in these patients. In this study, we investigated the difference in the expression of the glomerular glucocorticoid receptor (GCR) according to steroid responsiveness in 28 adult-onset MCD patients. METHODS: Based on the response to steroid treatment, the patients were divided into early responders (ER, n=20) and late responders (LR, n=8) according to the response to steroids on the basis of 4 weeks of treatment. The clinical and laboratory findings, and the glomerular mRNA and protein expression of GCR and nephrin, assessed by real-time polymerase chain reaction and immunohistochemistry, respectively, were compared between the ER and LR groups. Ten microscopic haematuric patients in whom renal biopsy was performed and revealed no histological abnormalities were included for control (C). RESULTS: The mRNA expression of GCR was significantly lower in the LR than that in the ER group (P<0.01), whereas it was comparable between the C and ER groups. GCR protein expression was also decreased in the LR compared with the C and ER groups. In contrast, there was no significant difference in nephrin mRNA expression among the three groups. On the other hand, the GCR mRNA expression correlated inversely with the time to complete remission (r= -0.49, P<0.05), but not with the amount of proteinuria at presentation. CONCLUSION: In conclusion, the levels of glomerular GCR expression may be a useful predictor of steroid responsiveness in adult-onset MCD patients.
Files in This Item:
T200800615.pdf Download
DOI
10.1093/ndt/gfm575
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kang, Shin Wook(강신욱) ORCID logo https://orcid.org/0000-0002-5677-4756
Kim, Dong Ki(김동기)
Moon, Sung Jin(문성진)
Park, Sun Young(박선영)
Lee, Jung Eun(이정은) ORCID logo https://orcid.org/0000-0003-0917-2872
Choi, Hoon Young(최훈영) ORCID logo https://orcid.org/0000-0002-4245-0339
Han, Dae Suk(한대석)
Han, Seung Hyeok(한승혁) ORCID logo https://orcid.org/0000-0001-7923-5635
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/106856
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