240 276

Cited 6 times in

Glomerular glucocorticoid receptor expression is reduced in late responders to steroids in adult-onset minimal change disease

DC FieldValueLanguage
dc.contributor.author문성진-
dc.contributor.author박선영-
dc.contributor.author최훈영-
dc.contributor.author한대석-
dc.contributor.author한승혁-
dc.contributor.author강신욱-
dc.contributor.author김동기-
dc.contributor.author이정은-
dc.date.accessioned2015-05-19T16:44:25Z-
dc.date.available2015-05-19T16:44:25Z-
dc.date.issued2008-
dc.identifier.issn0931-0509-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/106856-
dc.description.abstractBACKGROUND: Compared to children, adult patients with minimal change disease (MCD) tend to have a slower response to steroids, but little is known about the factors influencing the steroid responsiveness in these patients. In this study, we investigated the difference in the expression of the glomerular glucocorticoid receptor (GCR) according to steroid responsiveness in 28 adult-onset MCD patients. METHODS: Based on the response to steroid treatment, the patients were divided into early responders (ER, n=20) and late responders (LR, n=8) according to the response to steroids on the basis of 4 weeks of treatment. The clinical and laboratory findings, and the glomerular mRNA and protein expression of GCR and nephrin, assessed by real-time polymerase chain reaction and immunohistochemistry, respectively, were compared between the ER and LR groups. Ten microscopic haematuric patients in whom renal biopsy was performed and revealed no histological abnormalities were included for control (C). RESULTS: The mRNA expression of GCR was significantly lower in the LR than that in the ER group (P<0.01), whereas it was comparable between the C and ER groups. GCR protein expression was also decreased in the LR compared with the C and ER groups. In contrast, there was no significant difference in nephrin mRNA expression among the three groups. On the other hand, the GCR mRNA expression correlated inversely with the time to complete remission (r= -0.49, P<0.05), but not with the amount of proteinuria at presentation. CONCLUSION: In conclusion, the levels of glomerular GCR expression may be a useful predictor of steroid responsiveness in adult-onset MCD patients.-
dc.description.statementOfResponsibilityopen-
dc.formatapplication/pdf-
dc.relation.isPartOfNEPHROLOGY DIALYSIS TRANSPLANTATION-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdult-
dc.subject.MESHAge Factors-
dc.subject.MESHFemale-
dc.subject.MESHGlucocorticoids/therapeutic use*-
dc.subject.MESHHumans-
dc.subject.MESHKidney Glomerulus/drug effects*-
dc.subject.MESHKidney Glomerulus/metabolism*-
dc.subject.MESHMale-
dc.subject.MESHNephrosis, Lipoid/drug therapy*-
dc.subject.MESHPrednisolone/therapeutic use*-
dc.subject.MESHReceptors, Glucocorticoid/biosynthesis*-
dc.subject.MESHTime Factors-
dc.titleGlomerular glucocorticoid receptor expression is reduced in late responders to steroids in adult-onset minimal change disease-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학)-
dc.contributor.googleauthorSeung Hyeok Han-
dc.contributor.googleauthorSun Young Park-
dc.contributor.googleauthorJin-Ji Li-
dc.contributor.googleauthorSeung Jae Kwak-
dc.contributor.googleauthorDong Sub Jung-
dc.contributor.googleauthorHoon Young Choi-
dc.contributor.googleauthorJung Eun Lee-
dc.contributor.googleauthorSung Jin Moon-
dc.contributor.googleauthorDong Ki Kim-
dc.contributor.googleauthorDae-Suk Han-
dc.contributor.googleauthorShin-Wook Kang-
dc.identifier.doi10.1093/ndt/gfm575-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA01364-
dc.contributor.localIdA04226-
dc.contributor.localIdA04272-
dc.contributor.localIdA04304-
dc.contributor.localIdA00053-
dc.contributor.localIdA01499-
dc.contributor.localIdA00400-
dc.contributor.localIdA03119-
dc.relation.journalcodeJ02316-
dc.identifier.eissn1460-2385-
dc.identifier.pmid17890747-
dc.subject.keywordAdult-
dc.subject.keywordAge Factors-
dc.subject.keywordFemale-
dc.subject.keywordGlucocorticoids/therapeutic use*-
dc.subject.keywordHumans-
dc.subject.keywordKidney Glomerulus/drug effects*-
dc.subject.keywordKidney Glomerulus/metabolism*-
dc.subject.keywordMale-
dc.subject.keywordNephrosis, Lipoid/drug therapy*-
dc.subject.keywordPrednisolone/therapeutic use*-
dc.subject.keywordReceptors, Glucocorticoid/biosynthesis*-
dc.subject.keywordTime Factors-
dc.contributor.alternativeNameMoon, Sung Jin-
dc.contributor.alternativeNamePark, Sun Young-
dc.contributor.alternativeNameChoi, Hoon Young-
dc.contributor.alternativeNameHan, Dae Suk-
dc.contributor.alternativeNameHan, Seung Hyeok-
dc.contributor.alternativeNameKang, Shin Wook-
dc.contributor.alternativeNameKim, Dong Ki-
dc.contributor.affiliatedAuthorMoon, Sung Jin-
dc.contributor.affiliatedAuthorChoi, Hoon Young-
dc.contributor.affiliatedAuthorHan, Dae Suk-
dc.contributor.affiliatedAuthorHan, Seung Hyeok-
dc.contributor.affiliatedAuthorKang, Shin Wook-
dc.contributor.affiliatedAuthorPark, Sun Young-
dc.contributor.affiliatedAuthorKim, Dong Ki-
dc.contributor.affiliatedAuthorLee, Jung Eun-
dc.rights.accessRightsfree-
dc.citation.volume23-
dc.citation.number1-
dc.citation.startPage169-
dc.citation.endPage175-
dc.identifier.bibliographicCitationNEPHROLOGY DIALYSIS TRANSPLANTATION, Vol.23(1) : 169-175, 2008-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.