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토끼 심내막염 모델에서 Glycopeptide Intermediate Staphylococcus aureus에 대한 Arbekacin과 Teicoplanin 병용 요법의 효과

Other Titles
 Efficacy of the Arbekacin and Teicoplanin Combination on Glycopeptide Intermediate Staphylococcus aureus in a Rabbit Model of Endocarditis 
Authors
 Cheong Ho Cho  ;  Jun Yong Choi  ;  Sang Hoon Han  ;  Han Sung Lee  ;  Suk Hoon Choi  ;  Bum Sik Chin  ;  Hee Kyoung Choi  ;  Su Jin Jeoung  ;  Myung Soo Kim  ;  Chang Oh Kim  ;  Chang Ki Kim  ;  Dongeun Yong  ;  Young Goo Song  ;  Kyungwon Lee  ;  June Myung Kim 
Citation
 INFECTION AND CHEMOTHERAPY (감염과 화학요법), Vol.40(2) : 102-106, 2008 
Journal Title
INFECTION AND CHEMOTHERAPY (감염과 화학요법)(감염과 화학요법)
ISSN
 1598-8112 
Issue Date
2008
Keywords
Endocarditis, Staphylococcus aureus ; Teicoplanin ; Arbekacin
Abstract
BACKGROUND: There have been no reports to evaluate the usefulness of combination therapy with glycopeptide and arbekacin in endocarditis by in vivo model. MATERIALS AND METHODS: We investigated the efficacy of the arbekacin and teicoplanin combination on glycopeptide intermediate Staphylococcus aureus (GISA) in rabbit model of endocardits. GISA Mu50 strain was used for the experiment. The rabbit model of aortic valve endocarditis as described previously was used. Treatment was started 20h later inoculation with teicoplanin alone (at 20 mg/kg of body weight intramuscularly every 12 hours for 4 days after loading dose of 40 mg/kg of body weight intramuscularly), arbekacin alone (5 mg/kg of body weight intramuscularly every 12h for 4 days), or teicoplanin plus arbekacin. The results of therapy for experimental endocarditis due to Mu50 showed that teicoplanin and arbekacin combination was more effective than the administration of both drugs alone in reducing the log10CFU/g of aortic vegetation (P<0.05). CONCLUSION: The combination of teicoplanin and arbekacin was more effective against GISA (Mu50) than both drugs alone in vivo endocarditis model.
Files in This Item:
T200800571.pdf Download
DOI
10.3947/ic.2008.40.2.102
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers
Yonsei Authors
Kim, Myoung Soo(김명수)
Kim, June Myung(김준명)
Kim, Chang Ki(김창기)
Kim, Chang Oh(김창오) ORCID logo https://orcid.org/0000-0002-0773-5443
Song, Young Goo(송영구) ORCID logo https://orcid.org/0000-0002-0733-4156
Yong, Dong Eun(용동은) ORCID logo https://orcid.org/0000-0002-1225-8477
Lee, Kyungwon(이경원) ORCID logo https://orcid.org/0000-0003-3788-2134
Lee, Han Sung(이한성)
Jeong, Su Jin(정수진) ORCID logo https://orcid.org/0000-0003-4025-4542
Cho, Cheong Ho(조정호)
Chin, Bum Sik(진범식)
Choi, Suk Hoon(최석훈)
Choi, Jun Yong(최준용) ORCID logo https://orcid.org/0000-0002-2775-3315
Choi, Hee Kyoung(최희경)
Han, Sang Hoon(한상훈) ORCID logo https://orcid.org/0000-0002-4278-5198
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/106789
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