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기니 픽의 수술 후 장 폐색 모델에서 위장관 운동에 대한 Itopride Hydrochloride의 효과

Other Titles
 The Effect of Itopride Hydrochloride on the Gastrointestinal Motility in Postoperative Ileus of Guinea Pigs 
Authors
 임현철  ;  전누리  ;  최은주  ;  이영호  ;  이민구  ;  박효진 
Citation
 Korean Journal of Neurogastroenterology and Motility (대한소화관운동학회지), Vol.14(1) : 18-23, 2008 
Journal Title
 Korean Journal of Neurogastroenterology and Motility (대한소화관운동학회지) 
ISSN
 1226-2382 
Issue Date
2008
Keywords
postoperative ileus ; itopride hydrochloride ; gastrointestinal transit
Abstract
Backgrounds/Aim: Postoperative ileus (POI) is characterized by a transiently impaired propulsive function of the entire gastrointestinal tract which results from activated inhibitory sympathetic neural reflexes in the gut after abdominal surgery. Itopride hydrochloride (itopride) has been known as a gastroprokinetic agent which inhibits acetylcholinesterase and as antagonizes dopamine D2 receptor. The aim of this experiment is to clarify gastrointestinal motility effect of itopride in POI in guinea pigs. Methods: Open laparatomy was performed on guinea pig to induce POI. Charcoal was administered through orogastric tubes. The distance of charcoal migration from pylorus to the distal intestine was measured after administration of itopride 1, 3, 10, and 30 mg/kg. Additional experiments with infusion of dopamine and atropine was done to investigate its mechanism. Results: The gastrointestinal transit was significantly decreased in POI group compared with sham operation group. Itopride showed significant increase in the charcoal movement through the intestine compared with the POI group. A combination of dopamine or atropine with itopride displayed considerable decrease in the migration distance compared with that of itopride alone. Conclusions: POI group exhibited decrease in gastrointestinal motiliy, and conversely, administration of itopride promoted it through anti-dopaminergic and cholinergic mechanism.
Files in This Item:
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Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Physiology (생리학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pharmacology (약리학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Park, Hyo Jin(박효진) ORCID logo https://orcid.org/0000-0003-4814-8330
Lee, Min Goo(이민구) ORCID logo https://orcid.org/0000-0001-7436-012X
Lee, Young Ho(이영호) ORCID logo https://orcid.org/0000-0002-5749-1045
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/106686
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