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Survival benefit of combined curative resection of the stomach (D2 resection) and liver in gastric cancer patients with liver metastases

Authors
 S. H. Cheon  ;  S. Y. Rha  ;  H.-C. Jeung  ;  C.-K. Im  ;  S. H. Kim  ;  H. R. Kim  ;  J. B. Ahn  ;  J. K. Roh  ;  S. H. Noh  ;  H. C. Chung 
Citation
 ANNALS OF ONCOLOGY, Vol.19(6) : 1146-1153, 2008 
Journal Title
ANNALS OF ONCOLOGY
ISSN
 0923-7534 
Issue Date
2008
MeSH
Adenocarcinoma/secondary ; Adenocarcinoma/surgery* ; Adult ; Aged ; Female ; Gastrectomy/methods* ; Hepatectomy* ; Humans ; Liver Neoplasms/secondary ; Liver Neoplasms/surgery* ; Lymph Node Excision ; Male ; Middle Aged ; Stomach Neoplasms/pathology ; Stomach Neoplasms/surgery* ; Survival Analysis
Keywords
curative intent ; gastric cancer ; hepatic resection ; liver metastases
Abstract
BACKGROUND: The benefit of surgical resection of liver metastases from gastric cancer has not been well established. The aim of this study was to evaluate the rationale for hepatic resection in patients with hepatic metastases from gastric cancer. METHODS: Among 10 259 patients diagnosed with gastric adenocarcinoma in the Yonsei University Health System from 1995 to 2005, we reviewed the records of 58 patients with liver-only metastases from gastric cancer who underwent gastric resection regardless of hepatic surgery. RESULTS: The overall 1-year, 3-year, and 5-year survival rates of 41 patients who underwent hepatic resection with curative intent were 75.3%, 31.7%, and 20.8%, respectively, and three patients survived >7 years. Of the 41 patients, 22 had complete resection and 19 had palliative resection. Between the curative and palliative resections, survival rates after curative intent were not different. The number of liver metastasis (solitary or multiple) was a marginally significant prognostic factor for survival. CONCLUSIONS: Surgery for liver metastases arising from gastric adenocarcinoma is reasonable if complete resection seems feasible after careful preoperative staging, even if complete resection is not actually achieved. Hepatic resection should be considered as an option for gastric cancer patients with hepatic metastases.
Files in This Item:
T200800491.pdf Download
DOI
10.1093/annonc/mdn026
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
Yonsei Authors
Noh, Sung Hoon(노성훈) ORCID logo https://orcid.org/0000-0003-4386-6886
Roh, Jae Kyung(노재경)
Rha, Sun Young(라선영) ORCID logo https://orcid.org/0000-0002-2512-4531
Ahn, Joong Bae(안중배) ORCID logo https://orcid.org/0000-0001-6787-1503
Im, Chong Kun(임종근)
Cheon, Seong Ha(전성하)
Chung, Hyun Cheol(정현철) ORCID logo https://orcid.org/0000-0002-0920-9471
Jeung, Hei Cheul(정희철) ORCID logo https://orcid.org/0000-0003-0952-3679
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/106674
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