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Chronic cerebral hypoperfusion protects against acute focal ischemia, improves motor function, and results in vascular remodeling

Authors
 Seo Hyun Kim  ;  Eun Hee Kim  ;  Byung In Lee  ;  Ji Hoe Heo 
Citation
 Current Neurovascular Research, Vol.5(1) : 28-36, 2008 
Journal Title
 Current Neurovascular Research 
ISSN
 1567-2026 
Issue Date
2008
MeSH
Analysis of Variance ; Animals ; Blood Vessels/pathology ; Brain/pathology ; Infarction, Middle Cerebral Artery/mortality ; Infarction, Middle Cerebral Artery/pathology ; Infarction, Middle Cerebral Artery/physiopathology* ; Infarction, Middle Cerebral Artery/prevention & control* ; Ischemic Preconditioning/methods* ; Male ; Motor Activity/physiology* ; Neurologic Examination/methods ; Rats ; Rats, Sprague-Dawley ; Reperfusion/methods ; Tetrazolium Salts ; Time Factors
Keywords
Cerebral arteries ; cerebral infarction ; focal ischemia ; chronic hypoperfusion ; vascular remodeling
Abstract
Atherosclerosis may cause severe stenosis of the arteries supplying the brain, which induces chronic cerebral hypoperfusion. Although an infarction often occurs in this area, it is uncertain how brain vessels respond to the chronic hypoperfusion or how the vascular responses are related to stroke severity when the area has been subjected to severe ischemia. To address these uncertainties, we induced chronic cerebral hypoperfusion in Sprague-Dawley rats with a bilateral common carotid artery ligation (BCAL). A middle cerebral artery occlusion/reperfusion (MCAO/R) was introduced with a nylon suture four weeks after either BCAL (BCAL-MCAO) or a sham operation (Sham-MCAO). Motor disability scores and infarct sizes, based on 2,3,5-triphenyltetrazolium chloride staining, were significantly reduced with BCAL-MCAO treatment compared with sham-MCAO treatment (P<0.01). The diameters of the posterior cerebral, posterior communicating, and basilar arteries on the brain surface were larger and more tortuous in BCAL-treated rats (P<0.01). The density of large capillary- and arteriole-sized vessels in the brain parenchyma also increased in BCAL-treated rats (P<0.05). Strokes were less severe when the vicinity subjected to infarction was preconditioned with chronic cerebral hypoperfusion. Increasing the vascular reserve with adaptive vascular remodeling may have contributed to this response
Full Text
http://www.eurekaselect.com/66413/article
DOI
18289019
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Medical Research Center (임상의학연구센터) > 1. Journal Papers
Yonsei Authors
Kim, Eun Hee(김은희)
Lee, Byung In(이병인)
Heo, Ji Hoe(허지회) ORCID logo https://orcid.org/0000-0001-9898-3321
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/106635
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