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Serum and tear levels of nerve growth factor in diabetic retinopathy patients

Authors
 KYOUNG SOO PARK  ;  SUNG SOO KIM  ;  JAE CHAN KIM  ;  HYEON CHANG KIM  ;  YONG SUN IM  ;  CHUL WOO AHN  ;  HYUNG KEUN LEE 
Citation
 American Journal of Ophthalmology, Vol.145(3) : 432-437, 2008 
Journal Title
 American Journal of Ophthalmology 
ISSN
 0002-9394 
Issue Date
2008
MeSH
Blood Glucose/analysis ; Cross-Sectional Studies ; Diabetes Mellitus, Type 2/blood ; Diabetic Retinopathy/blood* ; Diabetic Retinopathy/classification ; Enzyme-Linked Immunosorbent Assay ; Eye Proteins/metabolism* ; Female ; Glycated Hemoglobin A/metabolism ; Humans ; Male ; Middle Aged ; Nerve Growth Factor/blood* ; Tears/metabolism*
Keywords
Blood Glucose/analysis ; Cross-Sectional Studies ; Diabetes Mellitus, Type 2/blood ; Diabetic Retinopathy/blood* ; Diabetic Retinopathy/classification ; Enzyme-Linked Immunosorbent Assay ; Eye Proteins/metabolism* ; Female ; Glycated Hemoglobin A/metabolism ; Humans ; Male ; Middle Aged ; Nerve Growth Factor/blood* ; Tears/metabolism*
Abstract
PURPOSE: To measure serum and tear nerve growth factor (NGF) concentrations in diabetic retinopathy (DR) patients to determine whether the NGF correlated with parameters associated with DR. DESIGN: Cross-sectional comparative study. METHODS: The study enrolled 254 DR patients and 71 nondiabetic controls. Patient demographic characteristics and diabetic parameters, including blood sugar levels, HbA1c, liver and renal function, were evaluated in two separate university hospitals. Serum and tear NGF concentrations and the ratio of NGF to total protein (TP) in serum and tear fluid were determined. RESULTS: Serum and tear NGF levels were found to be higher in proliferative diabetic retinopathy (PDR) patients (98.7+/-12.1 ng/ml in serum, 45.6+/-6.3 ng/ml in tear) than in nondiabetic controls (18.5+/-6.1 ng/ml in serum and 8.3+/-4.7 ng/ml in tear) and nonproliferative diabetic retinopathy (NPDR) patients (26.6+/-5.1 ng/ml in serum and 8.6+/-4.2 ng/ml in tear; p<.001 for both serum and tear differences). Similarly, NGF levels were higher in PDR patients than in controls and NPDR patients after adjusting for possible confounding factors such as age, gender, serum blood urea nitrogen, creatinine, and diabetic parameters. In addition, the NGF-to-TP ratio for both serum and tear fluid was higher in the PDR group compared with the control and NPDR groups. NGF levels correlated well with diabetes duration, HbA1c, and blood sugar levels and diabetic nephropathy. CONCLUSIONS: NGF concentration may be a good parameter for evaluating DR status. In addition, serum and tear NGF concentrations correlated strongly, indicating that tear fluid assays may offer an effective, accurate, and noninvasive option for NGF measurement
Full Text
http://www.sciencedirect.com/science/article/pii/S0002939407009816
DOI
10.1016/j.ajo.2007.11.011
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Ophthalmology (안과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Preventive Medicine and Public Health (예방의학교실) > 1. Journal Papers
Yonsei Authors
Kim, Sung Soo(김성수) ORCID logo https://orcid.org/0000-0002-0574-7993
Kim, Hyeon Chang(김현창) ORCID logo https://orcid.org/0000-0001-7867-1240
Ahn, Chul Woo(안철우) ORCID logo https://orcid.org/0000-0003-3733-7486
Lee, Hyung Keun(이형근) ORCID logo https://orcid.org/0000-0002-1123-2136
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/106550
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