1 611

Cited 23 times in

Risk factors and outcomes of bloodstream infections with metallo-beta-lactamase-producing Acinetobacter

Authors
 YEON-A KIM  ;  JUN YONG CHOI  ;  CHANG KI KIM  ;  CHANG OH KIM  ;  MYUNG SOO KIM  ;  SUK HOON CHOI  ;  BUM SIK CHIN  ;  SANG HOON HAN  ;  HAN SUNG LEE  ;  HEE KYOUNG CHOI  ;  SU JIN JEOUNG  ;  YOUNG GOO SONG  ;  JONG HWA YUM  ;  DONGEUN YONG  ;  KYUNGWON LEE  ;  JUNE MYUNG KIM 
Citation
 SCANDINAVIAN JOURNAL OF INFECTIOUS DISEASES, Vol.40(3) : 234-240, 2008 
Journal Title
SCANDINAVIAN JOURNAL OF INFECTIOUS DISEASES
ISSN
 0036-5548 
Issue Date
2008
MeSH
Acinetobacter/classification ; Acinetobacter/drug effects* ; Acinetobacter/enzymology ; Acinetobacter/isolation & purification ; Acinetobacter Infections/drug therapy ; Acinetobacter Infections/epidemiology ; Acinetobacter Infections/microbiology* ; Acinetobacter Infections/physiopathology ; Adult ; Aged ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/therapeutic use ; Bacteremia/drug therapy ; Bacteremia/epidemiology ; Bacteremia/microbiology* ; Bacteremia/physiopathology ; Carbapenems/pharmacology ; Carbapenems/therapeutic use ; Case-Control Studies ; Cephalosporins/pharmacology ; Cephalosporins/therapeutic use ; DNA Fingerprinting ; DNA, Bacterial/genetics ; Drug Resistance, Bacterial* ; Electrophoresis, Gel, Pulsed-Field ; Female ; Humans ; Male ; Middle Aged ; Neutropenia/complications ; Retrospective Studies ; Risk Factors ; Time Factors ; Treatment Outcome ; beta-Lactamases/biosynthesis*
Keywords
Acinetobacter/classification ; Acinetobacter/drug effects* ; Acinetobacter/enzymology ; Acinetobacter/isolation & purification ; Acinetobacter Infections/drug therapy ; Acinetobacter Infections/epidemiology ; Acinetobacter Infections/microbiology* ; Acinetobacter Infections/physiopathology ; Adult ; Aged ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/therapeutic use ; Bacteremia/drug therapy ; Bacteremia/epidemiology ; Bacteremia/microbiology* ; Bacteremia/physiopathology ; Carbapenems/pharmacology ; Carbapenems/therapeutic use ; Case-Control Studies ; Cephalosporins/pharmacology ; Cephalosporins/therapeutic use ; DNA Fingerprinting ; DNA, Bacterial/genetics ; Drug Resistance, Bacterial* ; Electrophoresis, Gel, Pulsed-Field ; Female ; Humans ; Male ; Middle Aged ; Neutropenia/complications ; Retrospective Studies ; Risk Factors ; Time Factors ; Treatment Outcome ; beta-Lactamases/biosynthesis*
Abstract
The spread of Gram-negative bacilli with acquired metallo-beta-lactamase (MBL) threatens the successful treatment of major nosocomial infections. The objective of this study was to evaluate the differences in the clinical characteristics of bacteremia caused by MBL-producing Acinetobacter species and MBL non-producing isolates. Two retrospective case-control studies were conducted using data on patients with Acinetobacter bacteremia, who were admitted between January 2001 and December 2005 at a 1500-bed, tertiary-care teaching hospital. Case group 1 (n=27) included patients from whom imipenem-resistant Acinetobacter was isolated in blood culture, and case group 2 (n=7) consisted of those patients from group 1 who yielded MBL-producing isolates. The control group (n=41) included patients from whom carbapenem-susceptible Acinetobacter isolates were isolated in blood culture. Multivariate analysis revealed that the independent risk factors for imipenem-resistant Acinetobacter bacteremia were neutropenia and prolonged use of carbapenem. The independent risk factors for MBL-producing Acinetobacter bacteremia were neutropenia and prolonged use of cephalosporins. The results of this study suggest that a prolonged use of cephalosporins may be associated with MBL-producing Acinetobacter bacteremia.
Full Text
http://informahealthcare.com/doi/abs/10.1080/00365540701633004
DOI
10.1080/00365540701633004
Appears in Collections:
1. College of Medicine (의과대학) > Research Institute (부설연구소) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers
Yonsei Authors
Kim, Myoung Soo(김명수)
Kim, Yeon A(김연아)
Kim, June Myung(김준명)
Kim, Chang Ki(김창기)
Kim, Chang Oh(김창오) ORCID logo https://orcid.org/0000-0002-0773-5443
Song, Young Goo(송영구) ORCID logo https://orcid.org/0000-0002-0733-4156
Yum, Jong Hwa(염종화)
Yong, Dong Eun(용동은) ORCID logo https://orcid.org/0000-0002-1225-8477
Lee, Kyungwon(이경원) ORCID logo https://orcid.org/0000-0003-3788-2134
Lee, Han Sung(이한성)
Jeong, Su Jin(정수진) ORCID logo https://orcid.org/0000-0003-4025-4542
Chin, Bum Sik(진범식)
Choi, Suk Hoon(최석훈)
Choi, Jun Yong(최준용) ORCID logo https://orcid.org/0000-0002-2775-3315
Choi, Hee Kyoung(최희경)
Han, Sang Hoon(한상훈) ORCID logo https://orcid.org/0000-0002-4278-5198
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/106521
사서에게 알리기
  feedback

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse

Links