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가족기반 코호트 연구의 사례와 전망

Other Titles
 Examples and outlook of family-based cohort study 
Authors
 설재웅  ;  박수경  ;  오희철  ;  지선하 
Citation
 Korean Journal of Epidemiology (한국역학회지), Vol.30(1) : 49-59, 2008 
Journal Title
 Korean Journal of Epidemiology (한국역학회지) 
ISSN
 1225-3596 
Issue Date
2008
Keywords
Family-based cohort study ; transmission disequilibrium test (TDT) ; linkage study
Abstract
Family-based designs are commonly used in genetic association studies to identify and to locate genes that underlie complex diseases. In this paper, we review two examples of genome-wide association studies using family-based cohort studies, including the Framingham Heart Study and International Multi-Center ADHD Genetics Project. We also review statistical methods of family-based designs, including the transmission disequilibrium test (TDT), linkage analysis, and imprinting effect analysis. In addition, we evaluate the strengths and limitations of the family-based cohort design. Despite the costs and difficulties in carrying out this type of study, a family-based cohort study can play avery important role in genome wide studies. First, the design will be free from biases due to population heterogeneity or stratification. Moreover, family-based designs provide the opportunity to conduct joint tests of linkage and association. Finally, family-based designs also allow access to epigenetic phenomena like imprinting. The family-based cohort design should be given careful consideration in planning new studies for genome-wide strategies
Files in This Item:
T200800328.pdf Download
DOI
10.4178/kje.2008.30.1.49
Appears in Collections:
4. Graduate School of Public Health (보건대학원) > Graduate School of Public Health (보건대학원) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Preventive Medicine and Public Health (예방의학교실) > 1. Journal Papers
Yonsei Authors
Sull, Jae Woong(설재웅)
Ohrr, Hee Choul(오희철)
Jee, Sun Ha(지선하) ORCID logo https://orcid.org/0000-0001-9519-3068
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/106481
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