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가족기반 코호트 연구의 사례와 전망
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 지선하 | - |
dc.contributor.author | 설재웅 | - |
dc.contributor.author | 오희철 | - |
dc.date.accessioned | 2015-05-19T16:32:00Z | - |
dc.date.available | 2015-05-19T16:32:00Z | - |
dc.date.issued | 2008 | - |
dc.identifier.issn | 1225-3596 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/106481 | - |
dc.description.abstract | Family-based designs are commonly used in genetic association studies to identify and to locate genes that underlie complex diseases. In this paper, we review two examples of genome-wide association studies using family-based cohort studies, including the Framingham Heart Study and International Multi-Center ADHD Genetics Project. We also review statistical methods of family-based designs, including the transmission disequilibrium test (TDT), linkage analysis, and imprinting effect analysis. In addition, we evaluate the strengths and limitations of the family-based cohort design. Despite the costs and difficulties in carrying out this type of study, a family-based cohort study can play avery important role in genome wide studies. First, the design will be free from biases due to population heterogeneity or stratification. Moreover, family-based designs provide the opportunity to conduct joint tests of linkage and association. Finally, family-based designs also allow access to epigenetic phenomena like imprinting. The family-based cohort design should be given careful consideration in planning new studies for genome-wide strategies | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 49~59 | - |
dc.language | Korean Journal of Epidemiology | - |
dc.publisher | Korean Journal of Epidemiology | - |
dc.relation.isPartOf | Korean Journal of Epidemiology | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | 가족기반 코호트 연구의 사례와 전망 | - |
dc.title.alternative | Examples and outlook of family-based cohort study | - |
dc.type | Article | - |
dc.contributor.college | Graduate School of Public Health (보건대학원) | - |
dc.contributor.department | Graduate School of Public Health (보건대학원) | - |
dc.contributor.googleauthor | 설재웅 | - |
dc.contributor.googleauthor | 박수경 | - |
dc.contributor.googleauthor | 오희철 | - |
dc.contributor.googleauthor | 지선하 | - |
dc.identifier.doi | 10.4178/kje.2008.30.1.49 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A03965 | - |
dc.contributor.localId | A01942 | - |
dc.contributor.localId | A02419 | - |
dc.relation.journalcode | J02004 | - |
dc.identifier.pmid | Family-based cohort study ; transmission disequilibrium test (TDT) ; linkage study | - |
dc.subject.keyword | Family-based cohort study | - |
dc.subject.keyword | transmission disequilibrium test (TDT) | - |
dc.subject.keyword | linkage study | - |
dc.contributor.alternativeName | Jee, Sun Ha | - |
dc.contributor.alternativeName | Sull, Jae Woong | - |
dc.contributor.alternativeName | Ohrr, Hee Choul | - |
dc.contributor.affiliatedAuthor | Jee, Sun Ha | - |
dc.contributor.affiliatedAuthor | Sull, Jae Woong | - |
dc.contributor.affiliatedAuthor | Ohrr, Hee Choul | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 30 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 49 | - |
dc.citation.endPage | 59 | - |
dc.identifier.bibliographicCitation | Korean Journal of Epidemiology, Vol.30(1) : 49-59, 2008 | - |
dc.identifier.rimsid | 45949 | - |
dc.type.rims | ART | - |
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