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Factors contributing to resectability and seizure outcomes in 44 patients with ganglioglioma

Authors
 Young Seok Park  ;  Dong-Seok Kim  ;  Kyu-Won Shim  ;  Jung-Hee Kim  ;  Joong-Uhn Choi 
Citation
 CLINICAL NEUROLOGY AND NEUROSURGERY, Vol.110(7) : 667-673, 2008 
Journal Title
CLINICAL NEUROLOGY AND NEUROSURGERY
ISSN
 0303-8467 
Issue Date
2008
MeSH
Adolescent ; Adult ; Child ; Child, Preschool ; Disease-Free Survival ; Female ; Follow-Up Studies ; Ganglioglioma/complications ; Ganglioglioma/pathology ; Ganglioglioma/surgery* ; Humans ; Infratentorial Neoplasms/complications ; Infratentorial Neoplasms/pathology ; Infratentorial Neoplasms/surgery ; Magnetic Resonance Imaging ; Male ; Middle Aged ; Postoperative Complications* ; Retrospective Studies ; Risk Factors ; Seizures/etiology ; Seizures/pathology ; Seizures/surgery* ; Spinal Cord Neoplasms/complications ; Spinal Cord Neoplasms/pathology ; Spinal Cord Neoplasms/surgery ; Supratentorial Neoplasms/complications ; Supratentorial Neoplasms/pathology ; Supratentorial Neoplasms/surgery ; Treatment Outcome
Keywords
Ganglioglioma ; Epilespy surgery ; Seizures outcome ; Temporal lobe ; Infratentorial tumor
Abstract
OBJECTIVES: The purpose of this retrospective study was to evaluate causes contributing to surgical resectability and seizure outcomes depending on various clinical and surgical factors.

PATIENTS AND METHODS: The records of 44 patients with gangliogliomas surgically treated between April 1986 and March 2007, were retrospectively reviewed to assess presenting symptoms, resectability and seizure outcomes.

RESULTS: Tumors were located in the supratentorial areas in 33 cases, the infratentorial area in 9 cases and the spinal cord in 2 cases. Thirty-five cases underwent gross total removal and 9 cases underwent subtotal resection. Only 2 cases underwent postoperative radiotherapy and 2 cases underwent gamma knife surgery. Twenty-six patients presented seizure symptoms of which 22 cases were located in temporal lobe and 4 cases were located in the extratemporal lobe. Twenty-three patients (88.5%) were seizure-free after surgery. Two patients were Engel class II and another was Engel class III.

CONCLUSION: We concluded that tumor location and seizure-presenting symptoms are good predictors of gross total removal. Gross total removal of ganglioglioma had a better chance of leaving the patient seizure free after surgery rather incomplete resection. Our data do not support the concept that surgical methods, invasive monitoring and surrounding cortical malformation correlated with seizure-free outcome.
Full Text
http://www.sciencedirect.com/science/article/pii/S0303846708001248
DOI
10.1016/j.clineuro.2008.03.017
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurosurgery (신경외과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Dong Seok(김동석)
Kim, Jung Hee(김정희)
Park, Young Seok(박영석)
Shim, Kyu Won(심규원) ORCID logo https://orcid.org/0000-0002-9441-7354
Choi, Joong Uhn(최중언)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/106240
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