106 171

Cited 0 times in

Assessment of cerebral oxygen supply-demand balance by near-infrared spectroscopy during induction of anesthesia in patients undergoing coronary artery bypass graft surgery: comparison of midazolam with propofol

 Dae-Hee Kim  ;  Young Lan Kwak  ;  Soon Ho Nam  ;  Min-Soo Kim  ;  Eun-Mi Kim  ;  Jae-Kwang Shim 
 KOREAN JOURNAL OF ANESTHESIOLOGY, Vol.57(4) : 428-433, 2009 
Journal Title
Issue Date
Cerebral oxygen supply-demand balance ; Coronary artery bypass graft surgery ; Midazolam ; Near-infrared spectroscopy ; Propofol
BACKGROUND: Near-infrared spectroscopy (NIRS) continuously measures regional cerebral oxygen saturation (rSO2) noninvasively and has been shown to detect even small changes in cerebral oxygen supply-demand balance. Although widely used, only the effect of midazolam on cerebral blood flow has been studied in humans and evidence is lacking about its effect on cerebral metabolic rate. We therefore evaluated the effect of midazolam on cerebral oxygen supply-demand balance with NIRS. METHODS: Sixty patients undergoing elective coronary artery bypass graft surgery were randomly allocated into either midazolam (n = 30) or propofol (n = 30) group. rSO2 was recorded before induction while patients were breathing room air as baseline, after pre-oxygenation with 100% oxygen, after administration of either midazolam or propofol, after completion of administration of sufentanil and after tracheal intubation. Hemodynamic variables including cardiac index and mixed venous oxygen saturation were recorded at the same time points. RESULTS: rSO2 and hemodynamic variables were similar between the groups throughout the study period. After pre-oxygenation, rSO2 significantly increased compared to baseline in each group, and did not show any additional increase after administration of either midazolam or propofol and sufentanil in both groups. CONCLUSIONS: Midazolam preserves cerebral blood flow-metabolism coupling to a similar degree to propofol as assessed by near infrared spectroscopy
Files in This Item:
T200906137.pdf Download
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Anesthesiology and Pain Medicine (마취통증의학교실) > 1. Journal Papers
Yonsei Authors
Kwak, Young Lan(곽영란) ORCID logo https://orcid.org/0000-0002-2984-9927
Kim, Min Soo(김민수) ORCID logo https://orcid.org/0000-0001-8760-4568
Kim, Eun Mi(김은미)
Nam, Soon Ho(남순호)
Shim, Jae Kwang(심재광) ORCID logo https://orcid.org/0000-0001-9093-9692
사서에게 알리기


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.