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Assessment of cerebral oxygen supply-demand balance by near-infrared spectroscopy during induction of anesthesia in patients undergoing coronary artery bypass graft surgery: comparison of midazolam with propofol

DC FieldValueLanguage
dc.contributor.author남순호-
dc.contributor.author심재광-
dc.contributor.author곽영란-
dc.contributor.author김민수-
dc.contributor.author김은미-
dc.date.accessioned2015-04-24T17:46:11Z-
dc.date.available2015-04-24T17:46:11Z-
dc.date.issued2009-
dc.identifier.issn2005-6419-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/106034-
dc.description.abstractBACKGROUND: Near-infrared spectroscopy (NIRS) continuously measures regional cerebral oxygen saturation (rSO2) noninvasively and has been shown to detect even small changes in cerebral oxygen supply-demand balance. Although widely used, only the effect of midazolam on cerebral blood flow has been studied in humans and evidence is lacking about its effect on cerebral metabolic rate. We therefore evaluated the effect of midazolam on cerebral oxygen supply-demand balance with NIRS. METHODS: Sixty patients undergoing elective coronary artery bypass graft surgery were randomly allocated into either midazolam (n = 30) or propofol (n = 30) group. rSO2 was recorded before induction while patients were breathing room air as baseline, after pre-oxygenation with 100% oxygen, after administration of either midazolam or propofol, after completion of administration of sufentanil and after tracheal intubation. Hemodynamic variables including cardiac index and mixed venous oxygen saturation were recorded at the same time points. RESULTS: rSO2 and hemodynamic variables were similar between the groups throughout the study period. After pre-oxygenation, rSO2 significantly increased compared to baseline in each group, and did not show any additional increase after administration of either midazolam or propofol and sufentanil in both groups. CONCLUSIONS: Midazolam preserves cerebral blood flow-metabolism coupling to a similar degree to propofol as assessed by near infrared spectroscopy-
dc.description.statementOfResponsibilityopen-
dc.format.extent428~433-
dc.relation.isPartOfKOREAN JOURNAL OF ANESTHESIOLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleAssessment of cerebral oxygen supply-demand balance by near-infrared spectroscopy during induction of anesthesia in patients undergoing coronary artery bypass graft surgery: comparison of midazolam with propofol-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Anesthesiology (마취통증의학)-
dc.contributor.googleauthorDae-Hee Kim-
dc.contributor.googleauthorYoung Lan Kwak-
dc.contributor.googleauthorSoon Ho Nam-
dc.contributor.googleauthorMin-Soo Kim-
dc.contributor.googleauthorEun-Mi Kim-
dc.contributor.googleauthorJae-Kwang Shim-
dc.identifier.doi10.4097/kjae.2009.57.4.428-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA01256-
dc.contributor.localIdA02205-
dc.contributor.localIdA00172-
dc.contributor.localIdA00803-
dc.contributor.localIdA00463-
dc.relation.journalcodeJ01963-
dc.identifier.eissn2005-7563-
dc.subject.keywordCerebral oxygen supply-demand balance-
dc.subject.keywordCoronary artery bypass graft surgery-
dc.subject.keywordMidazolam-
dc.subject.keywordNear-infrared spectroscopy-
dc.subject.keywordPropofol-
dc.contributor.alternativeNameNam, Soon Ho-
dc.contributor.alternativeNameShim, Jae Kwang-
dc.contributor.alternativeNameKwak, Young Lan-
dc.contributor.alternativeNameKim, Min Soo-
dc.contributor.alternativeNameKim, Eun Mi-
dc.contributor.affiliatedAuthorNam, Soon Ho-
dc.contributor.affiliatedAuthorShim, Jae Kwang-
dc.contributor.affiliatedAuthorKwak, Young Lan-
dc.contributor.affiliatedAuthorKim, Eun Mi-
dc.contributor.affiliatedAuthorKim, Min Soo-
dc.citation.volume57-
dc.citation.number4-
dc.citation.startPage428-
dc.citation.endPage433-
dc.identifier.bibliographicCitationKOREAN JOURNAL OF ANESTHESIOLOGY, Vol.57(4) : 428-433, 2009-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Anesthesiology and Pain Medicine (마취통증의학교실) > 1. Journal Papers

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