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The reversal of drug-resistance in tumors using a drug-carrying nanoparticular system

Authors
 Kyung Taek Oh  ;  Hye Jung Baik  ;  A Hyeong Lee  ;  Young Taik Oh  ;  Yu Seok Youn  ;  Eun Seong Lee 
Citation
 INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, Vol.10(9) : 3776-3792, 2009 
Journal Title
 INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 
Issue Date
2009
MeSH
Animals ; Antineoplastic Agents/administration & dosage* ; Antineoplastic Agents/chemistry* ; Antineoplastic Agents/pharmacology ; Antineoplastic Agents/therapeutic use ; Doxorubicin/chemistry ; Doxorubicin/pharmacology ; Doxorubicin/therapeutic use ; Drug Resistance, Neoplasm* ; Drug Screening Assays, Antitumor ; Humans ; Nanocapsules/chemistry* ; Nanocapsules/therapeutic use ; Neoplasms/drug therapy* ; Neoplasms/pathology ; Tumor Microenvironment/drug effects
Keywords
drug delivery system ; multi-drug resistance ; nanoparticle ; tumor treatment
Abstract
Medical applications of nanoparticular systems have attracted considerable attention because of their potential use in therapeutic targeting of disease tissues and their lower level of toxicity against healthy tissue, relative to traditional pharmaceutical drugs. The use of nanoparticular systems has been shown to overcome the limitations of most anticancer drugs in clinical applications. In particular, the improved performance of smarted nanoparticular system for solving the drug resistance problems that typically interrupt tumor treatment has provided a promising strategy for successful tumor chemotherapy. This review highlights recent studies that have examined the therapeutic effect of nanoparticular systems on drug-resistant tumors and presents insight on how they work
Files in This Item:
T200905988.pdf Download
DOI
10.3390/ijms10093776
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
Yonsei Authors
Oh, Young Taik(오영택) ORCID logo https://orcid.org/0000-0002-4438-8890
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/105994
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