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바퀴항원 천식모델에서 기도내 바퀴항원과 CpG 병용 투여가 바퀴항원에 의한 알레르기 염증에 미치는 효과

Other Titles
 Intranasal Administration of Unmethylated CpG with Cockroach Antigen Prevents the Development of Cockroach-Induced Allergic Inflammation 
Authors
 손정호  ;  김주영  ;  이재현  ;  이용원  ;  홍천수  ;  박중원 
Citation
 Journal of Asthma, Allergy and Clinical Immunology (천식 및 알레르기), Vol.29(3) : 194-199, 2009 
Journal Title
 Journal of Asthma, Allergy and Clinical Immunology (천식 및 알레르기) 
ISSN
 1226-8739 
Issue Date
2009
Keywords
Cockroach ; CpG ; Asthma
Abstract
Background: Unmethylated CpG can induce Th1 and regulatory T cell immune responses and may modulate ovalbumin-induced mouse allergic asthma. However, the effects of CpG in a cockroach allergen asthma model have not yet been elucidated. Objective: To evaluate whether unmethylated CpG can prevent the development of indoor allergen-induced allergic asthma. Methods: Effects of CpG were evaluated using a cockroach allergen-induced mouse model. CpG and Blattella germanica (CR) allergen were co-administered intranasally, and methacholine airway hyperresponsiveness (MCh-AHR), inflammatory cells and cytokine profiles in BAL fluid and lung histology were evaluated. Result: Co-administration of CpG with CR allergen can prevent the development of MCh-AHR and allergic inflammation in a CR-induced asthma mouse model. Eosinophils, lymphocytes, macrophages and neutrophils in BAL fluid were decreased by the co-administration of unmethylated CpG in an OVA-induced asthma model. The expression of IL-5, IL-13 and IFN-γ in BAL fluid was attenuated by the CpG. Peribronchial, perivascular inflammation, and goblet cell hyperplasia in respiratory epithelium were also markedly attenuated by the CpG. Conclusion: These findings suggest that unmethylated CpG may have role in the immune modulation of allergic asthma induced by indoor allergens
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Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers
Yonsei Authors
Kim, Joo Young(김주영)
Park, Jung Won(박중원) ORCID logo https://orcid.org/0000-0003-0249-8749
Sohn, Jung Ho(손정호)
Lee, Yong Won(이용원)
Lee, Jae Hyun(이재현) ORCID logo https://orcid.org/0000-0002-0760-0071
Hong, Chein Soo(홍천수)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/105963
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