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바퀴항원 천식모델에서 기도내 바퀴항원과 CpG 병용 투여가 바퀴항원에 의한 알레르기 염증에 미치는 효과
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김주영 | - |
dc.contributor.author | 박중원 | - |
dc.contributor.author | 손정호 | - |
dc.contributor.author | 이용원 | - |
dc.contributor.author | 이재현 | - |
dc.contributor.author | 홍천수 | - |
dc.date.accessioned | 2015-04-24T17:43:58Z | - |
dc.date.available | 2015-04-24T17:43:58Z | - |
dc.date.issued | 2009 | - |
dc.identifier.issn | 1226-8739 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/105963 | - |
dc.description.abstract | Background: Unmethylated CpG can induce Th1 and regulatory T cell immune responses and may modulate ovalbumin-induced mouse allergic asthma. However, the effects of CpG in a cockroach allergen asthma model have not yet been elucidated. Objective: To evaluate whether unmethylated CpG can prevent the development of indoor allergen-induced allergic asthma. Methods: Effects of CpG were evaluated using a cockroach allergen-induced mouse model. CpG and Blattella germanica (CR) allergen were co-administered intranasally, and methacholine airway hyperresponsiveness (MCh-AHR), inflammatory cells and cytokine profiles in BAL fluid and lung histology were evaluated. Result: Co-administration of CpG with CR allergen can prevent the development of MCh-AHR and allergic inflammation in a CR-induced asthma mouse model. Eosinophils, lymphocytes, macrophages and neutrophils in BAL fluid were decreased by the co-administration of unmethylated CpG in an OVA-induced asthma model. The expression of IL-5, IL-13 and IFN-γ in BAL fluid was attenuated by the CpG. Peribronchial, perivascular inflammation, and goblet cell hyperplasia in respiratory epithelium were also markedly attenuated by the CpG. Conclusion: These findings suggest that unmethylated CpG may have role in the immune modulation of allergic asthma induced by indoor allergens | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 194~199 | - |
dc.relation.isPartOf | Journal of Asthma, Allergy and Clinical Immunology (천식 및 알레르기) | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | 바퀴항원 천식모델에서 기도내 바퀴항원과 CpG 병용 투여가 바퀴항원에 의한 알레르기 염증에 미치는 효과 | - |
dc.title.alternative | Intranasal Administration of Unmethylated CpG with Cockroach Antigen Prevents the Development of Cockroach-Induced Allergic Inflammation | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학) | - |
dc.contributor.googleauthor | 손정호 | - |
dc.contributor.googleauthor | 김주영 | - |
dc.contributor.googleauthor | 이재현 | - |
dc.contributor.googleauthor | 이용원 | - |
dc.contributor.googleauthor | 홍천수 | - |
dc.contributor.googleauthor | 박중원 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A01681 | - |
dc.contributor.localId | A01993 | - |
dc.contributor.localId | A02981 | - |
dc.contributor.localId | A03086 | - |
dc.contributor.localId | A00938 | - |
dc.contributor.localId | A04448-1 | - |
dc.relation.journalcode | J01251 | - |
dc.subject.keyword | Cockroach | - |
dc.subject.keyword | CpG | - |
dc.subject.keyword | Asthma | - |
dc.contributor.alternativeName | Kim, Joo Young | - |
dc.contributor.alternativeName | Park, Jung Won | - |
dc.contributor.alternativeName | Sohn, Jung Ho | - |
dc.contributor.alternativeName | Lee, Yong Won | - |
dc.contributor.alternativeName | Lee, Jae Hyun | - |
dc.contributor.alternativeName | Hong, Chein Soo | - |
dc.contributor.affiliatedAuthor | Park, Jung Won | - |
dc.contributor.affiliatedAuthor | Sohn, Jung Ho | - |
dc.contributor.affiliatedAuthor | Lee, Yong Won | - |
dc.contributor.affiliatedAuthor | Lee, Jae Hyun | - |
dc.contributor.affiliatedAuthor | Kim, Joo Young | - |
dc.contributor.affiliatedAuthor | Hong, Chein Soo | - |
dc.citation.volume | 29 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 194 | - |
dc.citation.endPage | 199 | - |
dc.identifier.bibliographicCitation | Journal of Asthma, Allergy and Clinical Immunology (천식 및 알레르기), Vol.29(3) : 194-199, 2009 | - |
dc.identifier.rimsid | 51473 | - |
dc.type.rims | ART | - |
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