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Role of serum prothrombin induced by vitamin K absence or antagonist-II in the early detection of hepatocellular carcinoma in patients with chronic hepatitis B virus infection

Authors
 YOUNG JOON YOON  ;  KWANG-HYUB HAN  ;  DO YOUNG KIM 
Citation
 SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY, Vol.44(7) : 861-866, 2009 
Journal Title
SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY
ISSN
 0036-5521 
Issue Date
2009
MeSH
Biomarkers/blood* ; Biomarkers, Tumor/blood ; Carcinoma, Hepatocellular/blood* ; Carcinoma, Hepatocellular/diagnosis ; Carcinoma, Hepatocellular/virology ; Diagnostic Imaging ; Female ; Hepatitis B, Chronic/complications* ; Humans ; Liver Neoplasms/blood* ; Liver Neoplasms/diagnosis ; Liver Neoplasms/virology ; Luminescence ; Male ; Middle Aged ; Proportional Hazards Models ; Protein Precursors/blood* ; Prothrombin ; ROC Curve ; Risk Factors ; Sensitivity and Specificity ; Survival Analysis
Keywords
Early detection ; hepatitis B virus ; hepatocellular carcinoma ; PIVKA-II
Abstract
OBJECTIVE: the role of serum prothrombin induced by vitamin K absence or antagonist-II (PIVKA-II) in the early detection of hepatocellular carcinoma (HCC) in patients with chronic hepatitis B virus (HBV) infection has not yet been clearly identified. the purpose of the study was to evaluate the sensitivity and specificity of PIVKA-II, alone or in combination with alpha-fetoprotein (AFP), for the detection of HCC during surveillance, and to determine whether PIVKA-II was a significant risk factor for patient survival.

MATERIAL and METHODS: During surveillance, 106 HCC cases and 100 non-HCC cases of chronic HBV infection were included. Sensitivity and specificity of AFP and PIVKA-II were obtained through cut-off values of 20 ng/ml and 40 mAU/ml, respectively. the Cox proportional hazards model was used to determine whether PIVKA-II would be a significant risk factor for patient survival.

RESULTS: the sensitivity rates of AFP and PIVKA-II were 57.5% (61/106) and 51.9% (55/106), respectively. of 45 patients negative for AFP, 22 were positive for PIVKA-II. A combination of AFP and PIVKA-II increased the sensitivity to 78.3% (83/106). the specificities of AFP and PIVKA-II were 88.0% and 97.0%, respectively. PIVKA-II was not a significant risk factor for patient survival after multivariate analysis.

CONCLUSIONS: PIVKA-II can be used as a tumor marker for the early detection of HCC in patients with chronic HBV infection, especially in combination with AFP.
Full Text
http://informahealthcare.com/doi/abs/10.1080/00365520902903034
DOI
10.1080/00365520902903034
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Do Young(김도영)
Yoon, Young Joon(윤영준)
Han, Kwang-Hyub(한광협) ORCID logo https://orcid.org/0000-0003-3960-6539
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/105914
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