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Role of serum prothrombin induced by vitamin K absence or antagonist-II in the early detection of hepatocellular carcinoma in patients with chronic hepatitis B virus infection

DC Field Value Language
dc.contributor.author김도영-
dc.contributor.author윤영준-
dc.contributor.author한광협-
dc.date.accessioned2015-04-24T17:42:26Z-
dc.date.available2015-04-24T17:42:26Z-
dc.date.issued2009-
dc.identifier.issn0036-5521-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/105914-
dc.description.abstractOBJECTIVE: the role of serum prothrombin induced by vitamin K absence or antagonist-II (PIVKA-II) in the early detection of hepatocellular carcinoma (HCC) in patients with chronic hepatitis B virus (HBV) infection has not yet been clearly identified. the purpose of the study was to evaluate the sensitivity and specificity of PIVKA-II, alone or in combination with alpha-fetoprotein (AFP), for the detection of HCC during surveillance, and to determine whether PIVKA-II was a significant risk factor for patient survival. MATERIAL and METHODS: During surveillance, 106 HCC cases and 100 non-HCC cases of chronic HBV infection were included. Sensitivity and specificity of AFP and PIVKA-II were obtained through cut-off values of 20 ng/ml and 40 mAU/ml, respectively. the Cox proportional hazards model was used to determine whether PIVKA-II would be a significant risk factor for patient survival. RESULTS: the sensitivity rates of AFP and PIVKA-II were 57.5% (61/106) and 51.9% (55/106), respectively. of 45 patients negative for AFP, 22 were positive for PIVKA-II. A combination of AFP and PIVKA-II increased the sensitivity to 78.3% (83/106). the specificities of AFP and PIVKA-II were 88.0% and 97.0%, respectively. PIVKA-II was not a significant risk factor for patient survival after multivariate analysis. CONCLUSIONS: PIVKA-II can be used as a tumor marker for the early detection of HCC in patients with chronic HBV infection, especially in combination with AFP.-
dc.description.statementOfResponsibilityopen-
dc.format.extent861~866-
dc.relation.isPartOfSCANDINAVIAN JOURNAL OF GASTROENTEROLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHBiomarkers/blood*-
dc.subject.MESHBiomarkers, Tumor/blood-
dc.subject.MESHCarcinoma, Hepatocellular/blood*-
dc.subject.MESHCarcinoma, Hepatocellular/diagnosis-
dc.subject.MESHCarcinoma, Hepatocellular/virology-
dc.subject.MESHDiagnostic Imaging-
dc.subject.MESHFemale-
dc.subject.MESHHepatitis B, Chronic/complications*-
dc.subject.MESHHumans-
dc.subject.MESHLiver Neoplasms/blood*-
dc.subject.MESHLiver Neoplasms/diagnosis-
dc.subject.MESHLiver Neoplasms/virology-
dc.subject.MESHLuminescence-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHProportional Hazards Models-
dc.subject.MESHProtein Precursors/blood*-
dc.subject.MESHProthrombin-
dc.subject.MESHROC Curve-
dc.subject.MESHRisk Factors-
dc.subject.MESHSensitivity and Specificity-
dc.subject.MESHSurvival Analysis-
dc.titleRole of serum prothrombin induced by vitamin K absence or antagonist-II in the early detection of hepatocellular carcinoma in patients with chronic hepatitis B virus infection-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학)-
dc.contributor.googleauthorYOUNG JOON YOON-
dc.contributor.googleauthorKWANG-HYUB HAN-
dc.contributor.googleauthorDO YOUNG KIM-
dc.identifier.doi10.1080/00365520902903034-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA02582-
dc.contributor.localIdA04268-
dc.contributor.localIdA00385-
dc.relation.journalcodeJ02632-
dc.identifier.eissn1502-7708-
dc.identifier.pmid19391065-
dc.identifier.urlhttp://informahealthcare.com/doi/abs/10.1080/00365520902903034-
dc.subject.keywordEarly detection-
dc.subject.keywordhepatitis B virus-
dc.subject.keywordhepatocellular carcinoma-
dc.subject.keywordPIVKA-II-
dc.contributor.alternativeNameKim, Do Young-
dc.contributor.alternativeNameYoon, Young Joon-
dc.contributor.alternativeNameHan, Kwang Hyup-
dc.contributor.affiliatedAuthorYoon, Young Joon-
dc.contributor.affiliatedAuthorHan, Kwang Hyup-
dc.contributor.affiliatedAuthorKim, Do Young-
dc.citation.volume44-
dc.citation.number7-
dc.citation.startPage861-
dc.citation.endPage866-
dc.identifier.bibliographicCitationSCANDINAVIAN JOURNAL OF GASTROENTEROLOGY, Vol.44(7) : 861-866, 2009-
dc.identifier.rimsid51435-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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