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트립토판 가수분해 효소 및 세로토닌-2A 수용체 유전자 다형성과 정서기질의 관련성

Other Titles
 Relationship of Tryptophan Hydroxylase and Serotonin 2A Receptor Gene Polymorphisms with Affective Temperaments 
 정경운  ;  강지인  ;  남궁  ;  김세주  ;  남궁기 
 Journal of Korean Society for Depressive and Bipolar Disorders (우울ㆍ조울병), Vol.7(2) : 126-130, 2009 
Journal Title
 Journal of Korean Society for Depressive and Bipolar Disorders (우울ㆍ조울병) 
Issue Date
Objectives:Increasing data support a continuum between mood disorders and affective temperaments which are suggested to be heritable. The aim of this study is to investigate the possible relationship between affective tem- peraments and polymorphisms of two candidate serotonergic genes, tryptophan hydroxylase 1 (TPH1) and sero- tonin receptor 2A (5-HT2A) genes. Methods:334 healthy college students were recruited. DNA was isolated from whole blood cells, and TPH1 and 5-HT2A polymorphisms were genotyped. Participants completed the 110- item version of the Temperament Evaluation of Memphis, Pisa, Paris, and San Diego autoquestionnaire (TEMPS- A) measuring five affective temperamental traits. Results:No significant association was shown between affec- tive temperaments and TPH1 and 5-HT2A gene polymorphisms. Conclusion:In Korean population, there was no significant association between affective temperaments and TPH1 and 5-HT2A gene polymorphisms. Further stu- dies will be needed in different ethnic groups to understand the genetic basis of affective temperaments.
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Psychiatry (정신과학교실) > 1. Journal Papers
Yonsei Authors
Kang, Jee In(강지인) ORCID logo https://orcid.org/0000-0002-2818-7183
Kim, Se Joo(김세주) ORCID logo https://orcid.org/0000-0002-5438-8210
Namkoong, Kee(남궁기) ORCID logo https://orcid.org/0000-0003-1400-8057
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