트립토판 가수분해 효소 및 세로토닌-2A 수용체 유전자 다형성과 정서기질의 관련성

Abstract

Objectives：Increasing data support a continuum between mood disorders and affective temperaments which are suggested to be heritable. The aim of this study is to investigate the possible relationship between affective tem- peraments and polymorphisms of two candidate serotonergic genes, tryptophan hydroxylase 1 (TPH1) and sero- tonin receptor 2A (5-HT2A) genes.

Methods：334 healthy college students were recruited. DNA was isolated from whole blood cells, and TPH1 and 5-HT2A polymorphisms were genotyped. Participants completed the 110- item version of the Temperament Evaluation of Memphis, Pisa, Paris, and San Diego autoquestionnaire (TEMPS- A) measuring five affective temperamental traits.

Results：No significant association was shown between affec- tive temperaments and TPH1 and 5-HT2A gene polymorphisms.

Conclusion：In Korean population, there was no significant association between affective temperaments and TPH1 and 5-HT2A gene polymorphisms. Further stu- dies will be needed in different ethnic groups to understand the genetic basis of affective temperaments.