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트립토판 가수분해 효소 및 세로토닌-2A 수용체 유전자 다형성과 정서기질의 관련성
DC Field | Value | Language |
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dc.contributor.author | 김세주 | - |
dc.contributor.author | 남궁기 | - |
dc.date.accessioned | 2015-04-24T17:37:41Z | - |
dc.date.available | 2015-04-24T17:37:41Z | - |
dc.date.issued | 2009 | - |
dc.identifier.issn | 1738-0960 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/105761 | - |
dc.description.abstract | Objectives:Increasing data support a continuum between mood disorders and affective temperaments which are suggested to be heritable. The aim of this study is to investigate the possible relationship between affective tem- peraments and polymorphisms of two candidate serotonergic genes, tryptophan hydroxylase 1 (TPH1) and sero- tonin receptor 2A (5-HT2A) genes. Methods:334 healthy college students were recruited. DNA was isolated from whole blood cells, and TPH1 and 5-HT2A polymorphisms were genotyped. Participants completed the 110- item version of the Temperament Evaluation of Memphis, Pisa, Paris, and San Diego autoquestionnaire (TEMPS- A) measuring five affective temperamental traits. Results:No significant association was shown between affec- tive temperaments and TPH1 and 5-HT2A gene polymorphisms. Conclusion:In Korean population, there was no significant association between affective temperaments and TPH1 and 5-HT2A gene polymorphisms. Further stu- dies will be needed in different ethnic groups to understand the genetic basis of affective temperaments. | - |
dc.description.statementOfResponsibility | open | - |
dc.format | application/pdf | - |
dc.relation.isPartOf | Journal of Korean Society for Depressive and Bipolar Disorders (우울ㆍ조울병) | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | 트립토판 가수분해 효소 및 세로토닌-2A 수용체 유전자 다형성과 정서기질의 관련성 | - |
dc.title.alternative | Relationship of Tryptophan Hydroxylase and Serotonin 2A Receptor Gene Polymorphisms with Affective Temperaments | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Psychiatry (정신과학) | - |
dc.contributor.googleauthor | 정경운 | - |
dc.contributor.googleauthor | 강지인 | - |
dc.contributor.googleauthor | 남궁 | - |
dc.contributor.googleauthor | 김세주 | - |
dc.contributor.googleauthor | 남궁기 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00084 | - |
dc.contributor.localId | A00604 | - |
dc.contributor.localId | A01240 | - |
dc.relation.journalcode | J01534 | - |
dc.contributor.alternativeName | Kim, Se Joo | - |
dc.contributor.alternativeName | Namkoong, Kee | - |
dc.contributor.affiliatedAuthor | Kim, Se Joo | - |
dc.contributor.affiliatedAuthor | Namkoong, Kee | - |
dc.citation.volume | 7 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 126 | - |
dc.citation.endPage | 130 | - |
dc.identifier.bibliographicCitation | Journal of Korean Society for Depressive and Bipolar Disorders (우울ㆍ조울병), Vol.7(2) : 126-130, 2009 | - |
dc.identifier.rimsid | 43273 | - |
dc.type.rims | ART | - |
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