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The effects of Hydroxyapatite/Chitosan (H/C) Block scaffold in One-wall Intrabony Defect of Beagle Dogs

 Sung-Tae Kim  ;  Dong-Jin Kim  ;  Yoo-Jung Um  ;  Gyung-Joon Chae  ;  Chang-Sung Kim  ;  Yong-Keun Lee  ;  Seong-Ho Choi 
 Biomaterials Research (생체재료학회지), Vol.13(4) : 121-127, 2009 
Journal Title
Biomaterials Research(생체재료학회지)
Issue Date
Bone substitutes ; Guided tissue regeneration ; Periodontal disease ; Tissue engineering ; Tissue scaffolds
The effect of Hydroxyapatite/Chitosan (H/C) block scaffold and HA/β-TCP (H/T) particle on the regeneration was
evaluated in one-wall intrabony defects in beagle dogs. Six male beagle dogs were used in this study. H/C block
scaffold was manufactured by freeze-dried method. One-wall intrabony periodontal defects (4 × 4 mm) were surgically
created. Prepared defects were randomly assigned and treated as follows. In surgical control group (C) the
defects were not filled. In HA/β-TCP group (H/T), defects were filled with HA/β-TCP particle bone graft material. In
HA/Chitosan block group (H/C), defects were filled with HA/Chitosan Block scaffold. In all groups, Mean values of
regenerated bone, regenerated cementum, connective tissue, and epithelium were measured. H/C group showed
less inflammatory reaction than other groups. It revealed good biocompatibility. This group also showed better
cementum regeneration than any other group. However, due to the relatively rapid resorption of chitosan, space
maintenance for regeneration seems to have been compromised. Bone regeneration was affected adversely with this
rapid resorption. More favorable bone regeneration was found in H/T group because proper space was maintained
with Β-TCP
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Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Dental Biomaterials and Bioengineering (치과생체재료공학교실) > 1. Journal Papers
2. College of Dentistry (치과대학) > Dept. of Periodontics (치주과학교실) > 1. Journal Papers
2. College of Dentistry (치과대학) > Dept. of Prosthodontics (보철과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Sung Tae(김성태)
Kim, Chang Sung(김창성) ORCID logo https://orcid.org/0000-0003-3902-1071
Um, Yoo Jung(엄유정)
Lee, Yong Keun(이용근)
Chae, Gyung Joon(채경준)
Choi, Seong Ho(최성호) ORCID logo https://orcid.org/0000-0001-6704-6124
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