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The application of Cyanoacrylate-based Filling Material for Surgically Created 1-wall Intrabony Defects in Dogs

Authors
 Ji Soon Im  ;  Ui Won Jung  ;  Yun Young Chang  ;  Je Young Yeon  ;  Yoo Jung Um  ;  Chang Sung Kim  ;  Kyeong Jun Park  ;  Seong Ho. Choi 
Citation
 Biomaterials Research (생체재료학회지), Vol.13(4) : 128-132, 2009 
Journal Title
Biomaterials Research(생체재료학회지)
ISSN
 1226-4601 
Issue Date
2009
Keywords
bone graft ; cyanoacrylate ; hydroxyapatite ; β- tricalcium phosphate
Abstract
Bone grafts are often used as part of a surgical protocol to regenerate periodontal structures. Hydroxyapatite (HA)
and β-tricalcium phosphate (β-TCP) are used as bone graft materials for periodontal regeneration. N-butyl-2-
cyanoacrylate is also used as a tissue adhesive because of its rapid adhesion to hard and soft tissue. We evaluated
the bioactive properties of HA/β-TCP and cyanoacrylate filling materials for clinical applications. In four male beagle
dogs, we bilaterally created 4 × 4 mm one-wall intrabony defects at the distal aspect of the second mandibular premolars,
and at the mesial aspect of the fourth mandibular premolars. These defects were either experimentally
treated with a HA/β-TCP and cyanoacrylate combination, cyanoacrylate only, or surgery with no filling material. The
dogs were killed eight weeks after surgery, and block sections of the defects were collected for histologic and
histometric analysis. Postoperative healing was uneventful. Histological analysis revealed no significant differences in
periodontal healing between the experimental sites that received grafted materials and those that did not. Only
small amounts of bone fill and cementum regeneration were observed. In this study, we expected that the osteogenic
filling material would become fixed in the bony defect more quickly and stably because of the adhesive ability
of cyanoacrylate; however, the combination filling material did not result in a higher amount of new bone and
cementum formation compared to surgery with no filling material
Files in This Item:
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Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Periodontics (치주과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Chang Sung(김창성) ORCID logo https://orcid.org/0000-0003-3902-1071
Um, Yoo Jung(엄유정)
Jung, Ui Won(정의원) ORCID logo https://orcid.org/0000-0001-6371-4172
Choi, Seong Ho(최성호) ORCID logo https://orcid.org/0000-0001-6704-6124
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/105656
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