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Influence of ketoanalogs supplementation on the progression in chronic kidney disease patients who had training on low-protein diet.

Authors
 JAE HYUN CHANG  ;  DONG KI KIM  ;  JUNG TAK PARK  ;  EA WHA KANG  ;  TAE HYUN YOO  ;  BEOM SEOK KIM  ;  KYU HUN CHOI  ;  HO YUNG LEE  ;  DAE-SUK HAN  ;  SUG KYUN SHIN 
Citation
 NEPHROLOGY, Vol.14(8) : 750-757, 2009 
Journal Title
 NEPHROLOGY 
ISSN
 1320-5358 
Issue Date
2009
MeSH
Adult ; Aged ; Amino Acids, Essential/administration & dosage* ; Chronic Disease ; Diet, Protein-Restricted* ; Dietary Supplements ; Disease Progression ; Female ; Glomerular Filtration Rate ; Humans ; Kidney Diseases/therapy* ; Male ; Middle Aged
Keywords
chronic kidney disease ; ketoanalogs ; low-protein diet
Abstract
AIM: A low-protein diet (LPD) is a conservative treatment in patients with chronic kidney disease (CKD) to improve uremic symptoms and slow the progression of renal dysfunction. However, the deleterious effects of protein restriction on nutritional status have raised concern. We investigated whether ketoanalogs supplementation in CKD patients who had training on LPD retards the progression of CKD and maintains nutritional status. METHODS: Data were collected retrospectively from 120 consecutive patients in the CKD stages III and IV. Firstly all patients were restricted to LPD alone for 6 months (LPD alone), and then ketoanalogs of essential amino acids (KA) were supplemented for 6 months. RESULTS: The adequate LPD had not achieved in both periods. The declining slopes of glomerular filtration rate (GFR) during the LPD + KA period were significantly lower than those during the LPD alone period. This improvement in GFR was apparent in both subjects with diabetics and non-diabetic patients. Mean serum total cholesterol levels decreased in LPD + KA compared with LPD alone period. However, serum albumin levels did not change. Responders showed a higher prevalence of diabetes and higher serum albumin levels during the LPD alone period. Multivariate analysis revealed that responsiveness to LPD + KA was independently related to diabetes (p = 0.006) and high serum albumin levels (p = 0.011) in the LPD alone period. CONCLUSION: KA supplementation on over LPD delayed the progression of CKD without deteriorating nutritional status, and initial serum albumin levels could be an independent factor
Full Text
http://onlinelibrary.wiley.com/doi/10.1111/j.1440-1797.2009.01115.x/abstract
DOI
10.1111/j.1440-1797.2009.01115.x
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kang, Ea Wha(강이화)
Kim, Dong Ki(김동기)
Kim, Beom Seok(김범석) ORCID logo https://orcid.org/0000-0002-5732-2583
Park, Jung Tak(박정탁) ORCID logo https://orcid.org/0000-0002-2325-8982
Shin, Sug Kyun(신석균)
Yoo, Tae Hyun(유태현) ORCID logo https://orcid.org/0000-0002-9183-4507
Lee, Ho Yung(이호영)
Chang, Jae Hyun(장제현)
Choi, Kyu Hun(최규헌) ORCID logo https://orcid.org/0000-0003-0095-9011
Han, Dae Suk(한대석)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/105619
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