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Influence of ketoanalogs supplementation on the progression in chronic kidney disease patients who had training on low-protein diet.

DC FieldValueLanguage
dc.contributor.author강이화-
dc.contributor.author김동기-
dc.contributor.author김범석-
dc.contributor.author박정탁-
dc.contributor.author신석균-
dc.contributor.author유태현-
dc.contributor.author이호영-
dc.contributor.author장제현-
dc.contributor.author최규헌-
dc.contributor.author한대석-
dc.date.accessioned2015-04-24T17:33:15Z-
dc.date.available2015-04-24T17:33:15Z-
dc.date.issued2009-
dc.identifier.issn1320-5358-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/105619-
dc.description.abstractAIM: A low-protein diet (LPD) is a conservative treatment in patients with chronic kidney disease (CKD) to improve uremic symptoms and slow the progression of renal dysfunction. However, the deleterious effects of protein restriction on nutritional status have raised concern. We investigated whether ketoanalogs supplementation in CKD patients who had training on LPD retards the progression of CKD and maintains nutritional status. METHODS: Data were collected retrospectively from 120 consecutive patients in the CKD stages III and IV. Firstly all patients were restricted to LPD alone for 6 months (LPD alone), and then ketoanalogs of essential amino acids (KA) were supplemented for 6 months. RESULTS: The adequate LPD had not achieved in both periods. The declining slopes of glomerular filtration rate (GFR) during the LPD + KA period were significantly lower than those during the LPD alone period. This improvement in GFR was apparent in both subjects with diabetics and non-diabetic patients. Mean serum total cholesterol levels decreased in LPD + KA compared with LPD alone period. However, serum albumin levels did not change. Responders showed a higher prevalence of diabetes and higher serum albumin levels during the LPD alone period. Multivariate analysis revealed that responsiveness to LPD + KA was independently related to diabetes (p = 0.006) and high serum albumin levels (p = 0.011) in the LPD alone period. CONCLUSION: KA supplementation on over LPD delayed the progression of CKD without deteriorating nutritional status, and initial serum albumin levels could be an independent factor-
dc.description.statementOfResponsibilityopen-
dc.format.extent750~757-
dc.relation.isPartOfNEPHROLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdult-
dc.subject.MESHAged-
dc.subject.MESHAmino Acids, Essential/administration & dosage*-
dc.subject.MESHChronic Disease-
dc.subject.MESHDiet, Protein-Restricted*-
dc.subject.MESHDietary Supplements-
dc.subject.MESHDisease Progression-
dc.subject.MESHFemale-
dc.subject.MESHGlomerular Filtration Rate-
dc.subject.MESHHumans-
dc.subject.MESHKidney Diseases/therapy*-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.titleInfluence of ketoanalogs supplementation on the progression in chronic kidney disease patients who had training on low-protein diet.-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학)-
dc.contributor.googleauthorJAE HYUN CHANG-
dc.contributor.googleauthorDONG KI KIM-
dc.contributor.googleauthorJUNG TAK PARK-
dc.contributor.googleauthorEA WHA KANG-
dc.contributor.googleauthorTAE HYUN YOO-
dc.contributor.googleauthorBEOM SEOK KIM-
dc.contributor.googleauthorKYU HUN CHOI-
dc.contributor.googleauthorHO YUNG LEE-
dc.contributor.googleauthorDAE-SUK HAN-
dc.contributor.googleauthorSUG KYUN SHIN-
dc.identifier.doi10.1111/j.1440-1797.2009.01115.x-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00074-
dc.contributor.localIdA00488-
dc.contributor.localIdA01654-
dc.contributor.localIdA02110-
dc.contributor.localIdA02526-
dc.contributor.localIdA03326-
dc.contributor.localIdA03469-
dc.contributor.localIdA04043-
dc.contributor.localIdA04272-
dc.contributor.localIdA00400-
dc.relation.journalcodeJ02315-
dc.identifier.eissn1440-1797-
dc.identifier.pmid20025684-
dc.identifier.urlhttp://onlinelibrary.wiley.com/doi/10.1111/j.1440-1797.2009.01115.x/abstract-
dc.subject.keywordchronic kidney disease-
dc.subject.keywordketoanalogs-
dc.subject.keywordlow-protein diet-
dc.contributor.alternativeNameKang, Ea Wha-
dc.contributor.alternativeNameKim, Dong Ki-
dc.contributor.alternativeNameKim, Beom Seok-
dc.contributor.alternativeNamePark, Jung Tak-
dc.contributor.alternativeNameShin, Sug Kyun-
dc.contributor.alternativeNameYoo, Tae Hyun-
dc.contributor.alternativeNameLee, Ho Yung-
dc.contributor.alternativeNameChang, Jae Hyun-
dc.contributor.alternativeNameChoi, Kyu Hun-
dc.contributor.alternativeNameHan, Dae Suk-
dc.contributor.affiliatedAuthorKang, Ea Wha-
dc.contributor.affiliatedAuthorKim, Beom Seok-
dc.contributor.affiliatedAuthorPark, Jung Tak-
dc.contributor.affiliatedAuthorShin, Sug Kyun-
dc.contributor.affiliatedAuthorYoo, Tae Hyun-
dc.contributor.affiliatedAuthorLee, Ho Yung-
dc.contributor.affiliatedAuthorChang, Jae Hyun-
dc.contributor.affiliatedAuthorChoi, Kyu Hun-
dc.contributor.affiliatedAuthorHan, Dae Suk-
dc.contributor.affiliatedAuthorKim, Dong Ki-
dc.citation.volume14-
dc.citation.number8-
dc.citation.startPage750-
dc.citation.endPage757-
dc.identifier.bibliographicCitationNEPHROLOGY, Vol.14(8) : 750-757, 2009-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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