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Establishing a surveillance network for severe lower respiratory tract infections in Korean infants and young children.

Authors
 J.-K. Chun  ;  J.-H. Lee  ;  H.-S. Kim  ;  H.-M. Cheong  ;  K. S. Kim  ;  C. Kang  ;  D. S. Kim 
Citation
 EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES, Vol.28(7) : 841-844, 2009 
Journal Title
 EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES 
ISSN
 0934-9723 
Issue Date
2009
MeSH
Child ; Child, Preschool ; Humans ; Infant ; Infant, Newborn ; Korea/epidemiology ; Pneumonia/epidemiology* ; Pneumonia/mortality ; Pneumonia/virology* ; Polymerase Chain Reaction/methods ; Prevalence ; Respiratory Tract Infections/epidemiology* ; Respiratory Tract Infections/mortality ; Respiratory Tract Infections/virology* ; Reverse Transcriptase Polymerase Chain Reaction/methods ; Virus Diseases/diagnosis* ; Virus Diseases/epidemiology* ; Virus Diseases/mortality ; Virus Diseases/virology ; Viruses/classification ; Viruses/isolation & purification
Abstract
To reduce morbidity and mortality through integrated case management, a pilot study to detect respiratory viruses in patients with acute lower respiratory infections (ALRIs) was designed as part of a nationwide surveillance for this disease in Korea. The study population consisted of hospitalized patients under the age of 5 years with bronchiolitis, pneumonia, croup, or acute respiratory distress syndrome. A prospective 6-month study was performed. Two hundred and ninety-seven nasopharyngeal secretions were collected and multiplex reverse transcriptase polymerase chain reactions (RT-PCR)/polymerase chain reactions (PCR) were performed to detect respiratory viruses. If there were any positive RT-PCR/PCR results, viral cultures were proceeded for confirmation. Respiratory viruses were identified in 49.6% of 296 patients. The detection rates were as follows: respiratory syncytial virus (RSV) was the most commonly detected in 52.7% (87/165), human metapneumovirus (hMPV) in 15.8%, human corona virus (hCoV) in 5.5%, adenovirus in 9.7%, human bocavirus (hBoV) in 5.5%, parainfluenza virus (PIV) in 3.6%, rhinovirus (RV) in 4.2%, and the influenza virus in 3% of the patients with ALRIs. The consistent rate of positive results between RT-PCR and viral culture was 92% (105/114). Using our methods to detect viral causes seemed to be acceptable for the national surveillance of severe acute respiratory infections in infants and children.
Full Text
http://link.springer.com/article/10.1007%2Fs10096-009-0701-0
DOI
10.1007/s10096-009-0701-0
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pediatrics (소아청소년과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Dong Soo(김동수)
Kim, Hyon Suk(김현숙) ORCID logo https://orcid.org/0000-0001-5662-7740
Lee, Jong Han(이종한)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/105294
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