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Body mass index and stroke mortality by smoking and age at menopause among Korean postmenopausal women

Authors
 Sang-Wook Yi  ;  Nemekhee Odongua  ;  Chung Mo Nam  ;  Jae Woong Sull  ;  Heechoul Ohrr 
Citation
 STROKE, Vol.40(11) : 3428-3435, 2009 
Journal Title
STROKE
ISSN
 0039-2499 
Issue Date
2009
MeSH
Age Factors ; Aged ; Asian Continental Ancestry Group* ; Body Mass Index* ; Cohort Studies ; Female ; Follow-Up Studies ; Humans ; Korea ; Menopause*/physiology ; Middle Aged ; Obesity/complications ; Obesity/mortality ; Postmenopause*/physiology ; Prospective Studies ; Risk Factors ; Smoking/adverse effects ; Smoking/mortality* ; Smoking/physiopathology ; Stroke/mortality* ; Stroke/physiopathology
Keywords
Asian ; cohort study ; body mass index ; Korean ; menopause ; mortality ; smoking ; stroke
Abstract
BACKGROUND AND PURPOSE: The association between body mass index and mortality caused by subtypes of stroke among postmenopausal women in terms of smoking status and age at menopause remains controversial. METHODS: The data were derived from a cohort study of 3321 with 17.8 years of follow-up (1985 to 2002). Hazard ratios (HRs) and 95% CIs for strokes as related to body mass index were estimated by Cox proportional hazard models adjusted for age, hypertension, smoking, drinking, occupation, education, self-reported health, and age at menopause. A stratified analysis was conducted by age at menopause and smoking status. RESULTS: The obese group (body mass index >or=27.5 kg/m(2)) had higher risks of total stroke mortality (HR, 1.59; 95% CI, 1.05 to 2.42) and hemorrhagic stroke mortality (HR, 2.91; 95% CI, 1.37 to 6.19) than the normal weight group (18.5<or= body mass index <23.0). Among ever smokers, the obese group showed significantly increased risks of total stroke mortality (HR, 2.33; 95% CI, 1.00 to 5.43) and ischemic stroke mortality (HR, 7.21; 95% CI, 1.18 to 44.3). Obesity had more effect on stroke mortality among women who experienced menopause at age <50 than women with age >or=50. For the obese group of the former, the HR of total stroke was 2.04 (95% CI, 1.25 to 3.34) and that of hemorrhagic stroke 6.46 (95% CI, 2.42 to 17.25). CONCLUSIONS: In this prospective study, obesity raised the risks of total stroke mortality and hemorrhagic stroke mortality among Korean menopausal women. It was more evident with women who experienced menopause at age <50. The obese group of ever smokers was at an increased risk of ischemic stroke mortality.
Files in This Item:
T200903640.pdf Download
DOI
10.1161/STROKEAHA.109.555144
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Preventive Medicine (예방의학교실) > 1. Journal Papers
4. Graduate School of Public Health (보건대학원) > Graduate School of Public Health (보건대학원) > 1. Journal Papers
Yonsei Authors
Nam, Chung Mo(남정모) ORCID logo https://orcid.org/0000-0003-0985-0928
Sull, Jae Woong(설재웅)
Ohrr, Hee Choul(오희철)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/105245
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