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Reduced activation in the mirror neuron system during a virtual social cognition task in euthymic bipolar disorder

Authors
 Eosu Kim  ;  Young-Chul Jung  ;  Jeonghun Ku  ;  Jae-Jin Kim  ;  Hyeongrae Lee  ;  So Young Kim  ;  Sun I. Kim  ;  Hyun-Sang Cho 
Citation
 Progress in Neuro-Psychopharmacology & Biological Psychiatry, Vol.33(8) : 1409-1416, 2009 
Journal Title
 Progress in Neuro-Psychopharmacology & Biological Psychiatry 
ISSN
 0278-5846 
Issue Date
2009
Abstract
Social cognition entails both cognitive and affective processing, and impairments in both have accounted for residual symptoms of bipolar disorder (BD). However, there has been a lack of studies identifying neural substrates responsible for social cognitive difficulties in BD patients. Fourteen euthymic BD patients and 14 healthy normal controls underwent functional MRI while performing a virtual reality social cognition task, which incorporated both cognitive and emotional dimensions, simulating real-world social situations. During the scanning, subjects tried to guess (attribute) possible reasons for expressed emotion of virtual humans (avatars) while viewing their facial expressions, just after observing their verbal and nonverbal (facial) expressions which were emotionally valenced (happy, angry and neutral). BD patients compared to normal controls showed delayed reaction times in emotional conditions, with comparable response accuracy. Healthy normal controls activated the right anterior cingulate cortex, inferior frontal, and insular cortex in emotional conditions contrasted with neutral control conditions, that is, the regions that have been related to empathic processes during viewing others' emotional expression. Relative to normal controls, BD patients showed reduced activations in the 'mirror neuron system', including the right inferior frontal cortex, premotor cortex, and insula, mainly in angry or happy condition. These results may suggest that, even during euthymic state, BD patients have difficulties in recruiting brain regions for the utilization of emotional cues as a means for understanding others. Clinical attention should be paid to emotion-related residual symptoms to help improve social outcomes in these patients.
Full Text
http://www.sciencedirect.com/science/article/pii/S0278584609002474
DOI
10.1016/j.pnpbp.2009.07.019
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Psychiatry (정신과학교실) > 1. Journal Papers
Yonsei Authors
김어수(Kim, Eosu) ORCID logo https://orcid.org/0000-0001-9472-9465
김재진(Kim, Jae Jin) ORCID logo https://orcid.org/0000-0002-1395-4562
정영철(Jung, Young Chul) ORCID logo https://orcid.org/0000-0002-0578-2510
조현상(Cho, Hyun Sang) ORCID logo https://orcid.org/0000-0003-1019-9941
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/105225
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